SCHEMBL435260

SCHEMBL435260

OC[C@H]1OC(O)[C@H](Oc2ccc(O)cc2)[C@@H](O)[C@@H]1O

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TYR P14679 4/20 0.66
POLB P06746 2/20 0.46
KDM4E B2RXH2 1/20 0.46
GAA P10253 1/20 0.46
MAPT P10636 1/20 0.46
G6PD P11413 1/20 0.46
MAPK1 P28482 1/20 0.46
ADRA1A P35348 1/20 0.46
PTGS2 P35354 1/20 0.46
CA12 O43570 2/20 0.44
CA1 P00915 2/20 0.44
CA2 P00918 2/20 0.44
CA4 P22748 2/20 0.44
CA5A P35218 2/20 0.44
CA7 P43166 2/20 0.44
CA9 Q16790 2/20 0.44
CA3 P07451 1/20 0.44
CA13 Q8N1Q1 1/20 0.44
CA14 Q9ULX7 1/20 0.44
NPC1 O15118 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL940139 1.00 TYR (0.66) TYRPOLBKDM4EGAAMAPT
SCHEMBL9014227 1.00 TYR (0.66) TYRPOLBKDM4EGAAMAPT
SCHEMBL9013983 1.00 TYR (0.66) TYRPOLBKDM4EGAAMAPT
SCHEMBL7690243 1.00 TYR (0.66) TYRPOLBKDM4EGAAMAPT
SCHEMBL18920263 1.00 TYR (0.66) TYRPOLBKDM4EGAAMAPT
SCHEMBL9014038 0.87 TYR (0.51) TYRPOLBKDM4EGAAMAPT
SCHEMBL291103 0.86 TYR (0.49) TYR
SCHEMBL6582069 0.86 TYR (0.49) TYRPOLB
SCHEMBL21045067 0.86 SLC5A2 (0.49) TYRCA12CA9
SCHEMBL869387 0.86 TYR (0.49) TYR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117442531-A Bright white composition, bright white essence and preparation method thereof 天津郁美净集团有限公司 2024-01-26 CN disclosed
CN-107400653-B Recombinant escherichia coli containing alpha-glycosidase gene and application thereof 浙江工业大学 2020-10-09 CN disclosed
US-9751063-B2 Emulsion compositions and applications therefor MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2017-09-05 US disclosed
EP-3204455-A1 HYDROPHILIC ETHYLENE OXIDE FREE EMULSIFIER COMPRISING DENDRIMERIC POLYHYDROXYLATED ESTER MOIETIES Momentive Performance Materials GmbH (DE) 2017-08-16 EP disclosed
EP-3079777-A1 EMULSION COMPOSITIONS AND APPLICATIONS THEREFOR Momentive Performance Materials Inc. (US) 2016-10-19 EP disclosed
WO-2016057317-A1 HYDROPHILIC ETHYLENE OXIDE FREE EMULSIFIER COMPRISING DENDRIMERIC POLYHYDROXYLATED ESTER MOIETIES MOMENTIVE PERFORMANCE MATERIALS GMBH (DE) 2016-04-14 WO disclosed
WO-2015089035-A1 EMULSION COMPOSITIONS AND APPLICATIONS THEREFOR MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2015-06-18 WO disclosed
US-20150157996-A1 EMULSION COMPOSITIONS AND APPLICATIONS THEREFOR MOMENTIVE PERFORMANCE MATERIALS INC. 2015-06-11 US disclosed
WO-2014081715-A1 COMPOSITIONS AND METHODS FOR THEIR DERMATOLOGICAL USE VITA NATURALE, LLC (US) 2014-05-30 WO disclosed
EP-2595600-A1 METHODS FOR INHIBITING TYROSINASE USING AN EXTRACT OF LAMINARIA SACCHARINA The Procter and Gamble Company (US) 2013-05-29 EP disclosed
WO-2012011906-A1 METHODS FOR INHIBITING TYROSINASE USING AN EXTRACT OF LAMINARIA SACCHARINA THE PROCTER & GAMBLE COMPANY (US) 2012-01-26 WO disclosed
US-20080279794-A1 Use of halogenated hydroxydiphenyl ether compounds for the treatment of the skin BASCHONG WERNER 2008-11-13 US disclosed
US-20080260667-A1 Use of halogenated hydroxydiphenyl ether compounds for the treatment of the skin BASCHONG WERNER 2008-10-23 US disclosed
US-20070219275-A1 Use of Benzophenone Uv Filters for Preventing Tanning BASCHONG WERNER 2007-09-20 US disclosed
EP-1737419-A2 USE OF BENZOPHENONE UV FILTERS FOR PREVENTING TANNING Ciba SC Holding AG (CH) 2007-01-03 EP disclosed
US-20060216252-A1 Use of halogenated hydroxydiphenyl ether compounds for the treatment of the skin CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2006-09-28 US disclosed
EP-1648400-A1 USE OF HALOGENATED HYDROXYDIPHENYL ETHER COMPOUNDS FOR THE TREATMENT OF THE SKIN Ciba SC Holding AG (CH) 2006-04-26 EP disclosed
WO-2005094772-A2 USE OF BENZOPHENONE UV FILTERS FOR PREVENTING TANNING CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2005-10-13 WO disclosed
WO-2005013931-A1 USE OF HALOGENATED HYDROXYDIPHENYL ETHER COMPOUNDS FOR THE TREATMENT OF THE SKIN CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2005-02-17 WO disclosed
EP-1366757-A1 Use of hydroxydiphenylether compounds for the treatment of skin Ciba SC Holding AG (CH) 2003-12-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070219275-A1 Use of Benzophenone Uv Filters for Preventing Tanning C1R, CBR3, AOC3 TYR 18/4885POLB 1805/4885KDM4E 322/4885
US-20150157996-A1 EMULSION COMPOSITIONS AND APPLICATIONS THEREFOR POLR1C, POLQ, POLH TYR 35/4885POLB 16/4885KDM4E 3500/4885
US-20080260667-A1 Use of halogenated hydroxydiphenyl ether compounds for the treatment of the skin MC1R, TYR, MC3R TYR 2/4885POLB 3109/4885KDM4E 1289/4885
US-20080279794-A1 Use of halogenated hydroxydiphenyl ether compounds for the treatment of the skin MC1R, TYR, MC3R TYR 2/4885POLB 3109/4885KDM4E 1289/4885
US-20060216252-A1 Use of halogenated hydroxydiphenyl ether compounds for the treatment of the skin MC1R, TYR, MC3R TYR 2/4885POLB 3028/4885KDM4E 1147/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.