Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 16/20 | 0.97 |
| ▸ | OPRM1 | P35372 | 11/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.56 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.47 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11077198 | 0.98 | OPRL1 (0.97) | OPRL1OPRM1OPRK1MBTD1L3MBTL3 | |
| SCHEMBL2779077 | 0.98 | OPRL1 (1.00) | OPRL1OPRM1OPRK1MBTD1L3MBTL3 | |
| Hydrochloric Acid SCHEMBL2784498 | 0.97 | OPRL1 (1.00) | OPRL1OPRM1OPRK1MBTD1L3MBTL3 | |
| Hydrochloric Acid SCHEMBL11078593 | 0.97 | OPRL1 (0.94) | OPRL1OPRM1OPRK1MBTD1L3MBTL3 | |
| Hydrochloric Acid SCHEMBL11075754 | 0.85 | OPRL1 (1.00) | OPRL1OPRM1OPRK1 | |
| SCHEMBL11061930 | 0.78 | OPRL1 (0.67) | OPRL1OPRM1MBTD1L3MBTL3L3MBTL1 | |
| SCHEMBL2779771 | 0.78 | OPRL1 (0.60) | OPRL1OPRM1 | |
| Hydrochloric Acid SCHEMBL2781838 | 0.77 | OPRL1 (0.61) | OPRL1OPRM1 | |
| SCHEMBL4562996 | 0.76 | OPRL1 (0.60) | OPRL1OPRM1OPRK1MBTD1L3MBTL3 | |
| SCHEMBL2781912 | 0.76 | OPRL1 (0.58) | OPRL1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103183630-A | Substituted 4-aminocyclohexane derivatives | GRUENENTHAL GMBH | 2013-07-03 | — | — | CN | claimed |
| US-9580386-B2 | Substituted 4-aminocyclohexane derivatives | GRÜNENTHAL (DE) | 2017-02-28 | — | — | US | disclosed |
| US-9403767-B2 | Substituted 4-aminocyclohexane derivatives | GRUENENTHAL GMBH (DE) | 2016-08-02 | — | — | US | disclosed |
| US-20140357634-A1 | SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES | Grünenthal GmbH (DE) | 2014-12-04 | — | — | US | disclosed |
| US-8835689-B2 | Substituted 4-aminocyclohexane derivatives | Grünenthal GmbH (DE) | 2014-09-16 | — | — | US | disclosed |
| CN-102046595-B | Substituted 4-aminocyclohexane derivatives | GRUENENTHAL GMBH | 2014-03-05 | — | — | CN | disclosed |
| US-20130197095-A1 | SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES | Grünenthal GmbH (DE) | 2013-08-01 | — | — | US | disclosed |
| CN-103183630-A | Substituted 4-aminocyclohexane derivatives | GRUENENTHAL GMBH | 2013-07-03 | — | — | CN | disclosed |
| US-20120202810-A1 | SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES | GRUNENTHAL GMBH (DE) | 2012-08-09 | — | — | US | disclosed |
| US-20090247530-A1 | SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES | GRUNENTHAL GMBH (DE) | 2009-10-01 | — | — | US | disclosed |
| US-4447454-A | Analgetic compounds, compositions and process of treatment | THE UPJOHN COMPANY (US) | 1984-05-08 | — | — | US | disclosed |
| US-4113866-A | ANALGETIC COMPOUNDS, COMPOSITIONS AND PROCESS OF TREATMENT | THE UPJOHN COMPANY (US) | 1978-09-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140357634-A1 | SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES | OPRL1, OPRK1, OPRD1 | OPRL1 1/4885OPRM1 4/4885OPRK1 2/4885 |
| US-20090247530-A1 | SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES | OPRL1, OPRK1, OPRD1 | OPRL1 1/4885OPRM1 4/4885OPRK1 2/4885 |
| US-20120202810-A1 | SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES | OPRL1, OPRK1, OPRD1 | OPRL1 1/4885OPRM1 4/4885OPRK1 2/4885 |
| US-20130197095-A1 | SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES | OPRL1, OPRK1, OPRD1 | OPRL1 1/4885OPRM1 4/4885OPRK1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.