Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 12/20 | 0.85 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.67 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.67 |
| ▸ | PRKD2 | Q9BZL6 | 9/20 | 0.58 |
| ▸ | CCR2 | P41597 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL435269 | 1.00 | PRKCZ (0.85) | PRKCZROCK2ROCK1PRKD2CCR2 | |
| SCHEMBL528095 | 1.00 | PRKCZ (0.85) | PRKCZROCK2ROCK1PRKD2CCR2 | |
| Bicarbonate SCHEMBL27827793 | 0.94 | PRKCZ (0.76) | PRKCZROCK2ROCK1PRKD2 | |
| Bicarbonate SCHEMBL2112761 | 0.94 | PRKCZ (0.76) | PRKCZROCK2ROCK1PRKD2 | |
| SCHEMBL661175 | 0.92 | PRKCZ (1.00) | PRKCZROCK2ROCK1PRKD2 | |
| SCHEMBL660022 | 0.92 | PRKCZ (1.00) | PRKCZROCK2ROCK1PRKD2 | |
| SCHEMBL528390 | 0.92 | PRKCZ (1.00) | PRKCZROCK2ROCK1PRKD2 | |
| SCHEMBL5664354 | 0.92 | ROCK2 (0.74) | PRKCZROCK2ROCK1CCR2 | |
| Hydrochloric Acid SCHEMBL5662171 | 0.91 | PRKCZ (0.97) | PRKCZROCK2ROCK1PRKD2 | |
| Hydrochloric Acid SCHEMBL5662581 | 0.90 | ROCK2 (0.72) | PRKCZROCK2ROCK1CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102065689-A | RHO-kinase inhibitor compounds | INSPIRE PHARMACEUTICALS INC | 2011-05-18 | — | — | CN | claimed |
| US-20100022775-A1 | PROCESS FOR THE PREPARATION OF RHO-KINASE INHIBITOR COMPOUNDS | INSPIRE PHARMACEUTICALS, INC. | 2010-01-28 | — | — | US | claimed |
| EP-2914590-B1 | NOVEL ROCK INHIBITORS | PH PHARMA CO LTD (KR) | 2016-11-30 | — | — | EP | disclosed |
| EP-2914590-B1 | NOVEL ROCK INHIBITORS | PH PHARMA CO LTD (KR) | 2016-11-30 | — | — | EP | disclosed |
| US-9394286-B2 | Rock inhibitors | AMAKEM NV (BE) | 2016-07-19 | — | — | US | disclosed |
| US-9394286-B2 | Rock inhibitors | AMAKEM NV (BE) | 2016-07-19 | — | — | US | disclosed |
| US-20150299173-A1 | NOVEL ROCK INHIBTORS | AMAKEM NV (BE) | 2015-10-22 | — | — | US | disclosed |
| US-20150299173-A1 | NOVEL ROCK INHIBTORS | AMAKEM NV (BE) | 2015-10-22 | — | — | US | disclosed |
| EP-2914590-A1 | NOVEL ROCK INHIBITORS | Amakem NV (BE) | 2015-09-09 | — | — | EP | disclosed |
| WO-2014068035-A1 | NOVEL ROCK INHIBITORS | AMAKEM NV (BE) | 2014-05-08 | — | — | WO | disclosed |
| WO-2014068035-A1 | NOVEL ROCK INHIBITORS | AMAKEM NV (BE) | 2014-05-08 | — | — | WO | disclosed |
| US-20100022775-A1 | PROCESS FOR THE PREPARATION OF RHO-KINASE INHIBITOR COMPOUNDS | INSPIRE PHARMACEUTICALS, INC. | 2010-01-28 | — | — | US | disclosed |
| WO-2009154940-A1 | PROCESS FOR THE PREPARATION OF RHO-KINASE INHIBITOR COMPOUNDS | INSPIRE PHARMACEUTICALS, INC. (US) | 2009-12-23 | — | — | WO | disclosed |
| CN-101583361-A | Cytoskeletal Active RHO Kinase Inhibitor Compounds, Compositions and Uses | INSPIRE PHARMACEUTICALS INC (US) | 2009-11-18 | — | — | CN | disclosed |
| US-7615564-B2 | Isoquinoline derivatives having kinasae inhibitory activity and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2009-11-10 | — | — | US | disclosed |
| EP-2099457-A2 | CYTOSKELETAL ACTIVE RHO KINASE INHIBITOR COMPOUNDS, COMPOSITION AND USE | Inspire Pharmaceuticals, Inc. (US) | 2009-09-16 | — | — | EP | disclosed |
| US-20080214614-A1 | CYTOSKELETAL ACTIVE RHO KINASE INHIBITOR COMPOUNDS, COMPOSITION AND USE | MERCK SHARP & DOHME LLC | 2008-09-04 | — | — | US | disclosed |
| US-20080214614-A1 | CYTOSKELETAL ACTIVE RHO KINASE INHIBITOR COMPOUNDS, COMPOSITION AND USE | MERCK SHARP & DOHME LLC | 2008-09-04 | — | — | US | disclosed |
| US-20080214614-A1 | CYTOSKELETAL ACTIVE RHO KINASE INHIBITOR COMPOUNDS, COMPOSITION AND USE | MERCK SHARP & DOHME LLC | 2008-09-04 | — | — | US | disclosed |
| WO-2008077057-A2 | CYTOSKELETAL ACTIVE RHO KINASE INHIBITOR COMPOUNDS, COMPOSITION AND USE | INSPIRE PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150299173-A1 | NOVEL ROCK INHIBTORS | ROCK1, ROCK2, CIT | PRKCZ 83/4885ROCK2 2/4885ROCK1 1/4885 |
| US-20100022775-A1 | PROCESS FOR THE PREPARATION OF RHO-KINASE INHIBITOR COMPOUNDS | ROCK1, ROCK2, RHOA | PRKCZ 113/4885ROCK2 2/4885ROCK1 1/4885 |
| US-20080214614-A1 | CYTOSKELETAL ACTIVE RHO KINASE INHIBITOR COMPOUNDS, COMPOSITION AND USE | ROCK1, RHOA, ROCK2 | PRKCZ 192/4885ROCK2 3/4885ROCK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.