Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 4/20 | 0.55 |
| ▸ | TOP2A | P11388 | 3/20 | 0.55 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MGAM | O43451 | 1/20 | 0.48 |
| ▸ | SI | P14410 | 1/20 | 0.48 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.45 |
| ▸ | DDO | Q99489 | 1/20 | 0.45 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.45 |
| ▸ | SNCA | P37840 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PLTP | P55058 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433791 | 0.84 | NPC1 (0.58) | GAANPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL3738262 | 0.79 | TOP1 (0.58) | TOP1TOP2ATOP2BGAAMGAM | |
| SCHEMBL3569428 | 0.78 | NPC1 (0.71) | GAANPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL5557458 | 0.77 | MEN1 (0.57) | NPC1RAB9ASMN1; SMN2RPS6KA2KDM4E | |
| SCHEMBL1663709 | 0.77 | EGFR (0.47) | GAAMGAMSIMGAM2NPC1 | |
| SCHEMBL4669262 | 0.77 | NPC1 (0.57) | GAANPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL5894380 | 0.76 | GRIK1 (0.53) | GAANPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL1416715 | 0.76 | RPS6KA2 (0.47) | GAANPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL9269321 | 0.76 | GRIK1 (0.56) | GAANPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL13801599 | 0.75 | NPC1 (0.50) | NPC1RAB9ARPS6KA2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2039683-B1 | Vasculostatic agents and methods of use thereof | TARGEGEN INC (US) | 2012-12-19 | — | — | EP | disclosed |
| EP-2039683-A2 | Vasculostatic agents and methods of use thereof | Targegen, Inc. (US) | 2009-03-25 | — | — | EP | disclosed |
| CN-1720224-A | Vascular balancing agents and methods of use thereof | TARGEGEN INC (US) | 2006-01-11 | — | — | CN | disclosed |