Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | AHR | P35869 | 1/20 | 0.48 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.48 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3569428 | 0.78 | NPC1 (0.71) | NPC1LMNAGAARAB9AMAPT | |
| SCHEMBL7433791 | 0.78 | NPC1 (0.58) | NPC1LMNAGAAPKMRAB9A | |
| SCHEMBL4352826 | 0.77 | TOP1 (0.55) | NPC1LMNAGAARAB9ASMN1; SMN2 | |
| SCHEMBL9269321 | 0.76 | GRIK1 (0.56) | NPC1LMNAGAARAB9AMAPT | |
| SCHEMBL30316850 | 0.75 | NPC1 (0.49) | NPC1TP53LMNAGAAPKM | |
| SCHEMBL5515054 | 0.74 | GRIK1 (0.51) | NPC1LMNAGAARAB9AMAPT | |
| SCHEMBL5493171 | 0.74 | KDM4E (0.51) | NPC1LMNAGAARAB9AMAPT | |
| SCHEMBL31487774 | 0.74 | MTNR1A (0.53) | NPC1TP53LMNAGAARAB9A | |
| SCHEMBL4413986 | 0.74 | MTNR1A (0.53) | NPC1TP53LMNAGAARAB9A | |
| SCHEMBL22488985 | 0.74 | MAPT (0.62) | NPC1TP53LMNAGAAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2002838-A1 | Use of aryl and hetaryl amide derivatives as modulators of an EP2 receptor | Bayer Schering Pharma AG (DE) | 2008-12-17 | — | — | EP | disclosed |