Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 7/20 | 0.45 |
| ▸ | FEN1 | P39748 | 7/20 | 0.45 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 4/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 2/20 | 0.38 |
| ▸ | LYN | P07948 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | CTSA | P10619 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL397200 | 1.00 | ALOX5AP (0.45) | ALOX5APFEN1BCAT2KITMAPK14 | |
| SCHEMBL393447 | 0.82 | MAPK14 (0.56) | ALOX5APFEN1BCAT2KITMAPK14 | |
| SCHEMBL4576512 | 0.82 | MAPK14 (0.56) | ALOX5APFEN1BCAT2KITMAPK14 | |
| SCHEMBL4576490 | 0.82 | MAPK14 (0.56) | ALOX5APFEN1BCAT2KITMAPK14 | |
| SCHEMBL435291 | 0.82 | CDK2 (0.43) | MAPK14MAPK9KDRLCKLYN | |
| SCHEMBL437501 | 0.82 | CDK2 (0.43) | MAPK14MAPK9KDRLCKLYN | |
| SCHEMBL398063 | 0.78 | ALOX5AP (0.44) | ALOX5APFEN1BCAT2KITMAPK14 | |
| SCHEMBL4575830 | 0.78 | MAPK14 (0.52) | ALOX5APFEN1BCAT2KITMAPK14 | |
| SCHEMBL396560 | 0.76 | MAPK14 (0.55) | KITMAPK14MAPK9KDRMAPK10 | |
| SCHEMBL4232113 | 0.72 | BCAT2 (0.54) | ALOX5APFEN1BCAT2TRPV1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101612-B2 | N-3-isoxazolyl-4-methyl-3-(1-((1-methylethyl)oxy)-6-phthalazinyl)benzamide; p38 kinase inhibitor; antiinflammatory, analgesic agent; rheumatoid arthritis, osteoporosis, leukemia, psoriasis, Crohn's disease, rhinitis, ulcerative colitis, dermatitis, asthma, Alzheimer's disease, type I and II diabetes | AMGEN INC. (US) | 2012-01-24 | — | — | US | disclosed |
| US-20080119468-A1 | Phthalazine, aza-and diaza-phthalazine compounds and methods of use | AMGEN INC. (US) | 2008-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119468-A1 | Phthalazine, aza-and diaza-phthalazine compounds and methods of use | DAPK2, CDK2, DAPK1 | ALOX5AP 1577/4885FEN1 4509/4885BCAT2 3850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.