Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.40 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 4/20 | 0.39 |
| ▸ | DRD4 | P21917 | 4/20 | 0.39 |
| ▸ | DRD3 | P35462 | 4/20 | 0.39 |
| ▸ | UBE2M | P61081 | 1/20 | 0.38 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.38 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.37 |
| ▸ | SCD | O00767 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3948310 | 1.00 | KMT2A (0.47) | KMT2AL3MBTL1NPFFR1NPFFR2JAK1 | |
| SCHEMBL13631063 | 1.00 | KMT2A (0.47) | KMT2AL3MBTL1NPFFR1NPFFR2JAK1 | |
| SCHEMBL4297275 | 0.89 | HTR4 (0.41) | KMT2AL3MBTL1HTR4DRD2DRD4 | |
| SCHEMBL4297271 | 0.89 | HTR4 (0.41) | KMT2AL3MBTL1HTR4DRD2DRD4 | |
| SCHEMBL7825126 | 0.86 | KMT2A (0.52) | KMT2AL3MBTL1NPFFR1NPFFR2JAK1 | |
| SCHEMBL8741001 | 0.86 | KMT2A (0.52) | KMT2AL3MBTL1NPFFR1NPFFR2JAK1 | |
| SCHEMBL7825124 | 0.86 | KMT2A (0.52) | KMT2AL3MBTL1NPFFR1NPFFR2JAK1 | |
| SCHEMBL7825129 | 0.86 | KMT2A (0.52) | KMT2AL3MBTL1NPFFR1NPFFR2JAK1 | |
| SCHEMBL763170 | 0.83 | KMT2A (0.52) | KMT2AL3MBTL1NPFFR1NPFFR2JAK1 | |
| SCHEMBL3187533 | 0.82 | KMT2A (0.55) | KMT2AL3MBTL1NPFFR1NPFFR2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010488-A2 | RENIN INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007117559-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |