Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | PRCP | P42785 | 4/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 7/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.31 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6130853 | 0.75 | HRH4 (0.49) | HRH4HRH3PARP1 | |
| SCHEMBL4098296 | 0.74 | HRH4 (0.43) | HRH4HRH3PRCPPDE10AHCRTR1 | |
| SCHEMBL4354354 | 0.71 | HRH4 (0.44) | HRH4HRH3PRCPPDE10AHCRTR1 | |
| SCHEMBL4109197 | 0.66 | TXN (0.36) | HRH4HRH3PRCPPDE10AHCRTR1 | |
| SCHEMBL4345353 | 0.65 | PARP1 (0.48) | PARP1 | |
| SCHEMBL602120 | 0.64 | HRH4 (0.67) | HRH4HRH3 | |
| SCHEMBL4358469 | 0.61 | PDE10A (0.38) | HRH4HRH3PRCPPDE10AHCRTR1 | |
| SCHEMBL2511920 | 0.61 | HTR2B (0.47) | HRH4HRH3 | |
| SCHEMBL15844574 | 0.60 | SCN10A (0.58) | PDE10APARP1 | |
| SCHEMBL15844575 | 0.60 | SCN10A (0.58) | PDE10APARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504426-B2 | Heterocyclic compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-03-17 | — | — | US | claimed |