Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | MPO | P05164 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | PRCP | P42785 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4354354 | 0.84 | HRH4 (0.44) | PDE10AHRH4HRH3MPOOPRL1 | |
| SCHEMBL4109197 | 0.71 | TXN (0.36) | PDE10AHRH4HRH3OPRL1KCNH2 | |
| SCHEMBL4353639 | 0.69 | KDM4E (0.40) | ALDH1A1KDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4350354 | 0.69 | MPO (0.38) | PDE10AHRH4HRH3MPOOPRL1 | |
| SCHEMBL4356646 | 0.68 | HRH4 (0.45) | HRH4PRCPKDM4ECYP1A2CYP3A4 | |
| SCHEMBL4103942 | 0.66 | KCNH2 (0.40) | HRH4KCNH2HCRTR1HCRTR2 | |
| SCHEMBL4348250 | 0.65 | LMNA (0.39) | PDE10AHRH4ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL4352227 | 0.64 | HRH4 (0.35) | HRH4HRH3ALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL4356635 | 0.64 | HRH4 (0.47) | HRH4HRH3ALDH1A1 | |
| SCHEMBL604024 | 0.64 | HRH4 (0.60) | HRH4HRH3OPRL1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504426-B2 | Heterocyclic compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-03-17 | — | — | US | disclosed |