Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.88 |
| ▸ | HMGCR | P04035 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ACLY | P53396 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.41 |
| ▸ | CPT2 | P23786 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL4470699 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL8664261 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL29260319 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL11460124 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL4470695 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL4059637 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL29260318 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28629407 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28629408 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL3061288 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2217497-A | — | — | None | — | — | JP | disclosed |
| CN-108004555-B | Corrosion inhibiter composition and its application and the method that pickling is carried out to equipment | 中国石油化工股份有限公司 | 2019-11-12 | — | — | CN | disclosed |
| CN-108004554-B | Corrosion inhibiter composition and its application and the method that pickling is carried out to equipment | 中国石油化工股份有限公司 | 2019-09-27 | — | — | CN | disclosed |
| CN-109686946-A | A method of polynary positive pole material is prepared based on carbonate precursor | 宁波富理电池材料科技有限公司 | 2019-04-26 | — | — | CN | disclosed |
| CN-108004554-A | Corrosion inhibiter is with composition and its application and method that pickling is carried out to equipment | 中国石油化工股份有限公司 | 2018-05-08 | — | — | CN | disclosed |
| CN-108004555-A | Corrosion inhibiter is with composition and its application and method that pickling is carried out to equipment | 中国石油化工股份有限公司 | 2018-05-08 | — | — | CN | disclosed |
| US-20090286104-A1 | MULTI-LAYERED NICKEL-PHOSPHOROUS COATINGS AND PROCESSES FOR FORMING THE SAME | GENERAL ELECTRIC COMPANY (US) | 2009-11-19 | — | — | US | disclosed |
| CN-100408202-C | Electroless plating solution and process | MATTSON TECH INC (US) | 2008-08-06 | — | — | CN | disclosed |
| CN-1761534-A | Electroless plating solution and method | MATTSON TECH INC (US) | 2006-04-19 | — | — | CN | disclosed |
| US-6797312-B2 | DOES NOT REQUIRE THE USE OF A CATALYST, COMPRISING A FIRST REDUCING AGENT, A SECOND REDUCING AGENT, A PH ADJUSTING AGENT, A FIRST METAL SOURCE, AND A SECOND METAL SOURCE | MATTSON TECHNOLOGY, INC. | 2004-09-28 | — | — | US | disclosed |
| US-20040142114-A1 | Electroless plating solution and process | MATTSON TECHNOLOGY, INC. | 2004-07-22 | — | — | US | disclosed |
| EP-0674725-B1 | ELECTRODEPOSITION OF NICKEL-TUNGSTEN AMORPHOUS AND MICROCRYSTALLINE COATINGS | AMORPHOUS TECHNOLOGIES INTERNA (US) | 1998-12-02 | — | — | EP | disclosed |
| EP-0674725-A1 | ELECTRODEPOSITION OF NICKEL-TUNGSTEN AMORPHOUS AND MICROCRYSTALLINE COATINGS | AMORPHOUS TECHNOLOGIES INTERNATIONAL, INC. (US) | 1995-10-04 | — | — | EP | disclosed |
| US-5389226-A | Using bath containing nickel, tungsten, and boron compounds, and hydroxycarboxylic acid | AMORPHOUS TECHNOLOGIES INTERNATIONAL, INC. (US) | 1995-02-14 | — | — | US | disclosed |
| WO-1994013863-A1 | ELECTRODEPOSITION OF NICKEL-TUNGSTEN AMORPHOUS AND MICROCRYSTALLINE COATINGS | AMORPHOUS TECHNOLOGIES INTERNATIONAL, INC. (US) | 1994-06-23 | — | — | WO | disclosed |
| JP-H02217497-A | NICKEL-TUNGSTEN-SILICON CARBIDE COMPOSITE PLATING METHOD | TAKADA KENKYUSHO:KK | 1990-08-30 | — | — | JP | disclosed |