Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | PARP14 | Q460N5 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.32 |
| ▸ | TUBB | P07437 | 2/20 | 0.32 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.32 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.32 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.32 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.32 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.32 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.32 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.32 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.32 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.32 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10209810 | 0.83 | LMNA (0.37) | KDM4EPARP14RAB9AMAPTGAA | |
| SCHEMBL435471 | 0.80 | KDM4E (0.33) | KDM4EPARP14RAB9AMAPTGAA | |
| SCHEMBL10209683 | 0.79 | LMNA (0.39) | KDM4ERAB9AMAPTGAATDP1 | |
| SCHEMBL15180116 | 0.78 | TNKS2 (0.49) | KDM4EMAPTGAATDP1LMNA | |
| SCHEMBL433728 | 0.76 | KDM4E (0.35) | KDM4ERAB9AMAPTGAATDP1 | |
| SCHEMBL15180105 | 0.76 | LMNA (0.34) | KDM4ERAB9AMAPTGAATDP1 | |
| SCHEMBL431949 | 0.75 | MAPT (0.37) | KDM4EPARP14RAB9AMAPTGAA | |
| SCHEMBL988163 | 0.75 | MAPT (0.38) | KDM4ERAB9AMAPTGAATDP1 | |
| SCHEMBL459021 | 0.74 | RAB9A (0.45) | KDM4EPARP14RAB9ATDP1ALDH1A1 | |
| SCHEMBL15180112 | 0.71 | LMNA (0.34) | KDM4ERAB9AMAPTGAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595966-A2 | SYNTHESIS OF CYCLOPENTAQUINAZOLINES | Onyx Pharmaceuticals, Inc. (US) | 2013-05-29 | — | — | EP | claimed |
| WO-2012011939-A2 | SYNTHESIS OF CYCLOPENTAQUINAZOLINES | ONYX PHARMACEUTICALS, INC. (US) | 2012-01-26 | — | — | WO | claimed |