Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.56 |
| ▸ | TRPV1 | Q8NER1 | 10/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4354268 | 0.82 | TRPV1 (0.50) | HSD11B1TRPV1MALT1 | |
| SCHEMBL3210143 | 0.76 | HSD11B1 (0.51) | HSD11B1TRPV1MALT1 | |
| SCHEMBL30416776 | 0.76 | HSD11B1 (0.51) | HSD11B1TRPV1 | |
| SCHEMBL30416835 | 0.76 | HSD11B1 (0.51) | HSD11B1TRPV1 | |
| SCHEMBL13489654 | 0.76 | HSD11B1 (0.51) | HSD11B1TRPV1MALT1 | |
| SCHEMBL30417113 | 0.76 | HSD11B1 (0.51) | HSD11B1TRPV1MALT1 | |
| SCHEMBL14534288 | 0.75 | TRPV1 (0.57) | HSD11B1TRPV1 | |
| SCHEMBL28768958 | 0.75 | HSD11B1 (0.49) | HSD11B1 | |
| SCHEMBL27589696 | 0.74 | TRPV1 (0.54) | HSD11B1TRPV1MALT1 | |
| SCHEMBL27657082 | 0.73 | TRPV1 (0.60) | HSD11B1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090275628-A1 | Substituted Spiro-Compounds And The Use Thereof For Producing Medicaments | GRUENENTHAL GMBH (DE) | 2009-11-05 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275628-A1 | Substituted Spiro-Compounds And The Use Thereof For Producing Medicaments | REN, PKD1, PKD2 | HSD11B1 68/4885TRPV1 649/4885GRM4 2738/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.