Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 2/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.39 |
| ▸ | TAB1 | Q15750 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 3/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.38 |
| ▸ | CDK9 | P50750 | 2/20 | 0.38 |
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.38 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4355640 | 1.00 | KMT2A (0.46) | KMT2AMAP2K1AURKAAURKBHDAC1 | |
| SCHEMBL4346794 | 0.86 | KMT2A (0.45) | KMT2AMAP2K1AURKAAURKBHDAC1 | |
| SCHEMBL4346791 | 0.86 | KMT2A (0.45) | KMT2AMAP2K1AURKAAURKBHDAC1 | |
| Hydrochloric Acid SCHEMBL4349093 | 0.85 | AKT1 (0.45) | KMT2AAURKAAURKBHDAC1HDAC6 | |
| Hydrochloric Acid SCHEMBL4349100 | 0.85 | AKT1 (0.45) | KMT2AAURKAAURKBHDAC1HDAC6 | |
| SCHEMBL4358927 | 0.85 | AURKA (0.53) | KMT2AMAP2K1AURKAAURKBHDAC1 | |
| SCHEMBL4358930 | 0.85 | AURKA (0.53) | KMT2AMAP2K1AURKAAURKBHDAC1 | |
| SCHEMBL4348496 | 0.84 | KMT2A (0.41) | KMT2AMAP2K1HDAC1HDAC6MTNR1A | |
| SCHEMBL4348487 | 0.84 | KMT2A (0.41) | KMT2AMAP2K1HDAC1HDAC6MTNR1A | |
| SCHEMBL4513050 | 0.82 | AKT1 (0.56) | KMT2AAURKBAKT1GSK3BCDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | claimed |
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | disclosed |