Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MAP3K7 | O43318 | 5/20 | 0.39 |
| ▸ | TAB1 | Q15750 | 5/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 2/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 3/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4358930 | 1.00 | AURKA (0.53) | AURKAAURKBKMT2AHDAC1HDAC6 | |
| SCHEMBL4355640 | 0.85 | KMT2A (0.46) | AURKAAURKBKMT2AHDAC1HDAC6 | |
| SCHEMBL4355635 | 0.85 | KMT2A (0.46) | AURKAAURKBKMT2AHDAC1HDAC6 | |
| SCHEMBL4348278 | 0.84 | GSK3B (0.52) | AURKAAURKBKMT2AHDAC1HDAC6 | |
| SCHEMBL4348275 | 0.84 | GSK3B (0.52) | AURKAAURKBKMT2AHDAC1HDAC6 | |
| SCHEMBL4350722 | 0.84 | AURKA (0.46) | AURKAAURKBKMT2AHDAC1HDAC6 | |
| SCHEMBL4350717 | 0.84 | AURKA (0.46) | AURKAAURKBKMT2AHDAC1HDAC6 | |
| Hydrochloric Acid SCHEMBL4348331 | 0.84 | GSK3B (0.51) | AURKAAURKBKMT2AHDAC1HDAC6 | |
| Hydrochloric Acid SCHEMBL4348323 | 0.84 | GSK3B (0.51) | AURKAAURKBKMT2AHDAC1HDAC6 | |
| SCHEMBL4350437 | 0.83 | KMT2A (0.42) | AURKAAURKBKMT2AHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | claimed |
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | disclosed |