SCHEMBL4355746

SCHEMBL4355746

[SiH3]O[SiH](Cc1ccccc1)Cc1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.46
CALM1 P0DP23 1/20 0.39
IDO1 P14902 4/20 0.37
THRB P10828 1/20 0.37
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
ALDH1A1 P00352 2/20 0.36
TP53 P04637 1/20 0.36
LOXL2 Q9Y4K0 1/20 0.36
TRPA1 O75762 1/20 0.36
CYP3A4 P08684 2/20 0.36
MAPT P10636 2/20 0.36
AGXT P21549 1/20 0.36
KDM4E B2RXH2 1/20 0.36
MAOB P27338 1/20 0.35
HPGD P15428 1/20 0.35
ALOX15 P16050 1/20 0.35
ALOX12 P18054 1/20 0.35
CASP1 P29466 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28446741 0.79 TSHR (0.43) TSHRCALM1IDO1THRBTDP1
SCHEMBL19466456 0.79 CES1 (0.34) TSHR
SCHEMBL5016153 0.76 TSHR (0.39) TSHRCALM1IDO1THRBTDP1
SCHEMBL7101824 0.76 IDO1 (0.39) TSHRCALM1IDO1LOXL2AGXT
SCHEMBL2510929 0.76 TP53 (0.39) TSHRCALM1IDO1TDP1ALDH1A1
SCHEMBL3482739 0.75 TP53 (0.42) TSHRCALM1IDO1TDP1ALDH1A1
SCHEMBL30447961 0.75 TSHR (0.36) TSHRCALM1IDO1TDP1ALDH1A1
SCHEMBL19926905 0.73 TSHR (0.39) TSHRCALM1IDO1KMT2AALDH1A1
SCHEMBL28126538 0.73 TSHR (0.31) TSHRCALM1
SCHEMBL19926910 0.73 TP53 (0.41) TSHRTDP1ALDH1A1TP53LOXL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2133394-B1 METHOD FOR PRODUCING A FLAT-SURFACE INSULATING FILM-COATED SUBSTRATE AND FLAT-SURFACE INSULATING FILM-COATED SUBSTRATE NIPPON STEEL & SUMIKIN MAT CO (JP) 2014-12-31 EP disclosed
EP-2133394-A1 COATING SOLUTION FOR SURFACE FLAT INSULATING FORMATION, SURFACE FLAT INSULATING FILM COVERING BASE MATERIAL, AND PROCESS FOR PRODUCING SURFACE FLAT INSULATING FILM COVERING BASE MATERIAL Nippon Steel Materials Co., Ltd. (JP) 2009-12-16 EP disclosed
EP-0240254-A2 Polymerization catalyst, production and use EXXON CHEMICAL PATENTS INC. (US) 1987-10-07 EP disclosed