Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TKT | P29401 | 11/20 | 0.70 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.56 |
| ▸ | PPP5C | P53041 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13741845 | 0.99 | TKT (0.71) | TKTHSP90AA1PPP5CKDM4ETDP1 | |
| Hydrochloric Acid SCHEMBL2949884 | 0.85 | TKT (0.69) | TKTHSP90AA1PPP5CKDM4ETDP1 | |
| Hydrochloric Acid SCHEMBL14637039 | 0.84 | HSP90AA1 (0.61) | TKTHSP90AA1PPP5CKDM4ETDP1 | |
| SCHEMBL13741567 | 0.84 | TKT (0.68) | TKTHSP90AA1PPP5CKDM4ETDP1 | |
| Hydrochloric Acid SCHEMBL18879467 | 0.83 | HSP90AA1 (0.60) | TKTHSP90AA1PPP5CKDM4ETDP1 | |
| SCHEMBL13741796 | 0.82 | TKT (1.00) | TKT | |
| Hydrochloric Acid SCHEMBL5940670 | 0.81 | HSP90AA1 (0.57) | TKTHSP90AA1PPP5CKDM4ETDP1 | |
| Hydrochloric Acid SCHEMBL1533810 | 0.81 | PPP5C (0.67) | TKTHSP90AA1PPP5CKDM4ETDP1 | |
| SCHEMBL19598908 | 0.81 | PPP5C (0.50) | TKTHSP90AA1PPP5CKDM4ETDP1 | |
| SCHEMBL2512165 | 0.80 | PPP5C (0.68) | TKTHSP90AA1PPP5CKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090186358-A1 | Pathway Analysis of Cell Culture Phenotypes and Uses Thereof | WYETH (US) | 2009-07-23 | — | — | US | disclosed |
| EP-1392839-B1 | PREPARATION OF 2-KETO CARBOXYLIC ACID FROM CARBON DIOXIDE | NAT INST OF ADVANCED IND SCIEN (JP) | 2006-05-31 | — | — | EP | disclosed |