Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TKT | P29401 | 9/20 | 0.69 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PPP5C | P53041 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13741567 | 0.99 | TKT (0.68) | TKTHSP90AA1KDM4EPPP5CTDP1 | |
| Hydrochloric Acid SCHEMBL14637039 | 0.89 | HSP90AA1 (0.61) | TKTHSP90AA1KDM4EPPP5CTDP1 | |
| Hydrochloric Acid SCHEMBL18879467 | 0.88 | HSP90AA1 (0.60) | TKTHSP90AA1KDM4EPPP5CTDP1 | |
| Hydrochloric Acid SCHEMBL5940670 | 0.86 | HSP90AA1 (0.57) | TKTHSP90AA1KDM4EPPP5CTDP1 | |
| Hydrochloric Acid SCHEMBL4355811 | 0.85 | TKT (0.70) | TKTHSP90AA1KDM4EPPP5CTDP1 | |
| SCHEMBL13741845 | 0.84 | TKT (0.71) | TKTHSP90AA1KDM4EPPP5CTDP1 | |
| Hydrochloric Acid SCHEMBL3363419 | 0.81 | KDM4E (0.47) | TKTHSP90AA1KDM4EPPP5CTDP1 | |
| Hydrochloric Acid SCHEMBL1267295 | 0.81 | TKT (0.98) | TKT | |
| SCHEMBL12898292 | 0.80 | TKT (1.00) | TKT | |
| Hydrochloric Acid SCHEMBL19553812 | 0.79 | HSP90AA1 (0.52) | TKTHSP90AA1KDM4EPPP5CTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11236381-B2 | Method for checking and controlling the mammalian lactic acid fermentation process/aerobic glucose fermentation metabolic pathway in mammalian organism | COY JOHANNES (DE) | 2022-02-01 | — | — | US | claimed |
| US-10676777-B2 | — | — | 2020-06-09 | — | — | US | claimed |
| EP-2256500-B1 | Use of inhibitors of the enzyme TKTL1. | COY DR JOHANNES F (DE) | 2014-04-23 | — | — | EP | claimed |
| EP-2256500-A2 | Use of inhibitors of the enzyme TKTL1. | Coy, Johannes F., Dr. (DE) | 2010-12-01 | — | — | EP | claimed |
| US-20100240687-A1 | METHOD FOR CHECKING AND CONTROLLING THE MAMMALIAN LACTIC ACID FERMENTATION PROCESS/AEROBIC GLUCOSE FERMENTATION METABOLIC PATHWAY IN MAMMALIAN ORGANISM | COY JOHANNES | 2010-09-23 | — | — | US | claimed |
| US-20080095703-A1 | Method For Checking And Controlling The Mammalian Lactic Acid Fermentation Process / Aerobic Glucose Fermentation Metabolic Pathway In Mammalian Organism | COY JOHANNES | 2008-04-24 | — | — | US | claimed |
| EP-1856537-A1 | METHOD FOR CHECKING AND CONTROLLING THE MAMMALIAN LACTIC ACID FERMENTATION PROCESS/AEROBIC GLUCOSE FERMENTATION METABOLIC PATHWAY IN MAMMALIAN ORGANISM | Coy, Johannes, Dr. (DE) | 2007-11-21 | — | — | EP | claimed |
| WO-2006094716-A1 | METHOD FOR CKECKING AND CONTROLLING THE MAMMALIAN LACTIC ACID FERMENTATION PROCESS/AEROBIC GLUCOSE FERMENTATION METABOLIC PATHWAY IN MAMMALIAN ORGANISM | COY JOHANNES (DE) | 2006-09-14 | — | — | WO | claimed |
| EP-1701165-A1 | Therapeutic and diagnostic uses of TKTL1 and inhibitors and activators thereof | Coy, Johannes, Dr. (DE) | 2006-09-13 | — | — | EP | claimed |
| US-11359225-B2 | Method for checking and controlling the mammalian lactic acid fermentation process/aerobic glucose fermentation metabolic pathway in mammalian organism | COY JOHANNES (DE) | 2022-06-14 | — | — | US | disclosed |
| US-11236381-B2 | Method for checking and controlling the mammalian lactic acid fermentation process/aerobic glucose fermentation metabolic pathway in mammalian organism | COY JOHANNES (DE) | 2022-02-01 | — | — | US | disclosed |
| US-20200248227-A1 | METHOD FOR CHECKING AND CONTROLLING THE MAMMALIAN LACTIC ACID FERMENTATION PROCESS / AEROBIC GLUCOSE FERMENTATION METABOLIC PATHWAY IN MAMMALIAN ORGANISM | COY JOHANNES (DE) | 2020-08-06 | — | — | US | disclosed |
| US-10676777-B2 | — | — | 2020-06-09 | — | — | US | disclosed |
| EP-2256500-B1 | Use of inhibitors of the enzyme TKTL1. | COY DR JOHANNES F (DE) | 2014-04-23 | — | — | EP | disclosed |
| US-20100240687-A1 | METHOD FOR CHECKING AND CONTROLLING THE MAMMALIAN LACTIC ACID FERMENTATION PROCESS/AEROBIC GLUCOSE FERMENTATION METABOLIC PATHWAY IN MAMMALIAN ORGANISM | COY JOHANNES | 2010-09-23 | — | — | US | disclosed |
| US-7754437-B2 | Method for checking and controlling the mammalian lactic acid fermentation process / aerobic glucose fermentation metabolic pathway in mammalian organism | COY JOHANNES | 2010-07-13 | — | — | US | disclosed |
| US-20080095703-A1 | Method For Checking And Controlling The Mammalian Lactic Acid Fermentation Process / Aerobic Glucose Fermentation Metabolic Pathway In Mammalian Organism | COY JOHANNES | 2008-04-24 | — | — | US | disclosed |
| EP-1856537-A1 | METHOD FOR CHECKING AND CONTROLLING THE MAMMALIAN LACTIC ACID FERMENTATION PROCESS/AEROBIC GLUCOSE FERMENTATION METABOLIC PATHWAY IN MAMMALIAN ORGANISM | Coy, Johannes, Dr. (DE) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006094716-A1 | METHOD FOR CKECKING AND CONTROLLING THE MAMMALIAN LACTIC ACID FERMENTATION PROCESS/AEROBIC GLUCOSE FERMENTATION METABOLIC PATHWAY IN MAMMALIAN ORGANISM | COY JOHANNES (DE) | 2006-09-14 | — | — | WO | disclosed |
| EP-1701165-A1 | Therapeutic and diagnostic uses of TKTL1 and inhibitors and activators thereof | Coy, Johannes, Dr. (DE) | 2006-09-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080095703-A1 | Method For Checking And Controlling The Mammalian Lactic Acid Fermentation Process / Aerobic Glucose Fermentation Metabolic Pathway In Mammalian Organism | TKT, MDH1, GOT1 | TKT 1/4885HSP90AA1 2162/4885KDM4E 1606/4885 |
| US-20100240687-A1 | METHOD FOR CHECKING AND CONTROLLING THE MAMMALIAN LACTIC ACID FERMENTATION PROCESS/AEROBIC GLUCOSE FERMENTATION METABOLIC PATHWAY IN MAMMALIAN ORGANISM | TKT, SLC16A1, HOGA1 | TKT 1/4885HSP90AA1 1974/4885KDM4E 1590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.