Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | ACSS2 | Q9NR19 | 2/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | CCR2 | P41597 | 1/20 | 0.55 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.55 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 3/20 | 0.54 |
| ▸ | DRD4 | P21917 | 3/20 | 0.54 |
| ▸ | CTSL | P07711 | 1/20 | 0.53 |
| ▸ | CTSB | P07858 | 1/20 | 0.53 |
| ▸ | CTSK | P43235 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13211820 | 0.88 | NPC1 (0.61) | PKMACSS2CCR2GAANPSR1 | |
| SCHEMBL11245499 | 0.87 | PKM (0.54) | PKMACSS2GAADRD2DRD4 | |
| SCHEMBL13162925 | 0.83 | MEN1 (0.71) | CHRM1GAA | |
| SCHEMBL18286474 | 0.83 | CARM1 (0.72) | CARM1PRMT6DRD4NPSR1ADRA1D | |
| SCHEMBL4356360 | 0.82 | CTSL (0.57) | CHRM1CARM1PRMT6CTSLCTSB | |
| SCHEMBL10210847 | 0.82 | CTSL (0.57) | CHRM1CARM1PRMT6CTSLCTSB | |
| SCHEMBL12437666 | 0.80 | HRH3 (0.58) | PKMACSS2OPRM1 | |
| SCHEMBL25366529 | 0.79 | GAA (0.51) | ACSS2GAAGABRA5 | |
| SCHEMBL967298 | 0.79 | GAA (0.51) | ACSS2GAAGABRA5 | |
| SCHEMBL15031312 | 0.79 | PKM (0.47) | PKMACSS2GAAGABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2056829-A2 | USING PI3K AND MEK MODULATORS IN TREATMENTS OF CANCER | Exelixis, Inc. (US) | 2009-05-13 | — | — | EP | claimed |
| WO-2008021389-A2 | USING PI3K AND MEK MODULATORS IN TREATMENTS OF CANCER | EXELIXIS, INC. (US) | 2008-02-21 | — | — | WO | claimed |