Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.62 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | FBP1 | P09467 | 1/20 | 0.46 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4356366 | 0.86 | EGFR (0.60) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6993701 | 0.85 | EGFR (0.64) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8319458 | 0.84 | EGFR (0.59) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6995214 | 0.82 | EGFR (0.59) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6990991 | 0.81 | EGFR (0.59) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8314431 | 0.81 | EGFR (0.59) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8316049 | 0.81 | EGFR (0.59) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8313815 | 0.80 | EGFR (0.58) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8312893 | 0.80 | EGFR (0.64) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8798694 | 0.80 | EGFR (0.63) | EGFRERBB2HPGDHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070328-A1 | MODULATORS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) PATHWAY FOR USE IN THE TREATMENT OR PREVENTION OF SUBSTANCE ABUSE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-06-04 | — | — | WO | disclosed |