SCHEMBL4356366

SCHEMBL4356366

CC(CN1CCCCC1)Nc1ncc2ncnc(Nc3ccc(F)c(Cl)c3)c2n1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 19/20 0.60
ERBB2 P04626 6/20 0.60
HPGD P15428 1/20 0.60
HTT P42858 1/20 0.60
MAPT P10636 1/20 0.52
ERBB4 Q15303 4/20 0.49
JAK3 P52333 2/20 0.49
GRM1 Q13255 1/20 0.44
GAK O14976 1/20 0.44
RIPK2 O43353 1/20 0.44
NR1I2 O75469 1/20 0.44
LCK P06239 1/20 0.44
ADORA3 P0DMS8 1/20 0.44
CHRM1 P11229 1/20 0.44
SRC P12931 1/20 0.44
DRD2 P14416 1/20 0.44
ADRA2C P18825 1/20 0.44
SLC6A2 P23975 1/20 0.44
MC3R P41968 1/20 0.44
SLC6A3 Q01959 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8319418 0.92 EGFR (0.58) EGFRERBB2HPGDHTTMAPT
SCHEMBL4356375 0.86 EGFR (0.62) EGFRERBB2HPGDHTTMAPT
SCHEMBL6993701 0.85 EGFR (0.64) EGFRERBB2HPGDHTTMAPT
SCHEMBL8314431 0.85 EGFR (0.59) EGFRERBB2HPGDHTTMAPT
SCHEMBL8316049 0.85 EGFR (0.59) EGFRERBB2HPGDHTTMAPT
SCHEMBL6990991 0.85 EGFR (0.59) EGFRERBB2HPGDHTTMAPT
SCHEMBL8312893 0.82 EGFR (0.64) EGFRERBB2HPGDHTTMAPT
SCHEMBL6995214 0.82 EGFR (0.59) EGFRERBB2HPGDHTTMAPT
SCHEMBL4353386 0.81 EGFR (0.58) EGFRERBB2HPGDHTTMAPT
SCHEMBL6988056 0.81 EGFR (0.57) EGFRERBB2HPGDHTTMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009070328-A1 MODULATORS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) PATHWAY FOR USE IN THE TREATMENT OR PREVENTION OF SUBSTANCE ABUSE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2009-06-04 WO disclosed
EP-0888351-A1 PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION Dr. Karl Thomae GmbH (DE) 1999-01-07 EP disclosed
WO-1997032880-A1 PYRIMIDO[5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION DR. KARL THOMAE GMBH (DE) 1997-09-12 WO disclosed