Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9264721 | 0.84 | LMNA (0.38) | LMNAMEN1KMT2ANPC1MAPT | |
| SCHEMBL179333 | 0.81 | LMNA (0.50) | LMNAMEN1KMT2ANPC1MAPT | |
| SCHEMBL21762128 | 0.79 | LMNA (0.41) | LMNAMEN1KMT2ANPC1MAPT | |
| SCHEMBL17108555 | 0.77 | LMNA (0.40) | LMNAMEN1KMT2ANPC1MAPT | |
| SCHEMBL594622 | 0.77 | ADRB2 (0.43) | LMNAMEN1KMT2ANPC1MAPT | |
| SCHEMBL17154813 | 0.77 | LMNA (0.40) | LMNAMEN1KMT2ANPC1MAPT | |
| SCHEMBL2760656 | 0.77 | ADRB2 (0.43) | LMNAMEN1KMT2ANPC1MAPT | |
| SCHEMBL1856238 | 0.77 | SMN1; SMN2 (0.43) | SMN1; SMN2ADRA2AADRA2BADRA2CCYP2D6 | |
| SCHEMBL4252351 | 0.77 | SMN1; SMN2 (0.43) | SMN1; SMN2ADRA2AADRA2BADRA2CCYP2D6 | |
| SCHEMBL961068 | 0.77 | LMNA (0.40) | LMNAMEN1KMT2ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115626922-A | 5,6,7,8-tetrahydropyrido [4,3-d ] pyrimidin-4-ol derivatives and uses thereof | 苏州恩华生物医药科技有限公司 | 2023-01-20 | — | — | CN | disclosed |
| WO-2009111540-A1 | METHODS FOR PREPARING PYRIDYLETHYL-SUBSTITUTED CARBOLINES | MEDIVATION NEUROLOGY, INC. (US) | 2009-09-11 | — | — | WO | disclosed |
| WO-2009111540-A1 | METHODS FOR PREPARING PYRIDYLETHYL-SUBSTITUTED CARBOLINES | MEDIVATION NEUROLOGY, INC. (US) | 2009-09-11 | — | — | WO | disclosed |
| US-3969526-A | Anthelmintic 5-heterocycliothio and oxy-2-carbalkoxyaminobenzimidazles | SMITHKLINE CORPORATION (US) | 1976-07-13 | — | — | US | disclosed |