Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.57 |
| ▸ | KDR | P35968 | 7/20 | 0.52 |
| ▸ | CSF1R | P07333 | 6/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5084456 | 0.80 | EGFR (0.67) | EGFRKDRERBB2 | |
| SCHEMBL6266311 | 0.78 | EGFR (0.44) | EGFRKDRERBB2 | |
| Hydrochloric Acid SCHEMBL28090806 | 0.77 | EGFR (0.50) | EGFRKDRCSF1R | |
| SCHEMBL3647109 | 0.74 | EGFR (0.60) | EGFRKDRCSF1RERBB2 | |
| SCHEMBL27626897 | 0.73 | EGFR (0.59) | EGFRKDRERBB2 | |
| SCHEMBL6898447 | 0.73 | EGFR (0.49) | EGFRKDRCSF1RERBB2ENPP1 | |
| SCHEMBL15338461 | 0.72 | TRPA1 (0.58) | EGFRKDRCSF1RERBB2 | |
| SCHEMBL10883 | 0.72 | EGFR (1.00) | EGFRKDRERBB2 | |
| SCHEMBL9052 | 0.72 | EGFR (0.86) | EGFRKDRERBB2 | |
| SCHEMBL15084624 | 0.72 | EGFR (0.58) | EGFRKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070328-A1 | MODULATORS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) PATHWAY FOR USE IN THE TREATMENT OR PREVENTION OF SUBSTANCE ABUSE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-06-04 | — | — | WO | disclosed |