Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 12/20 | 0.75 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.50 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4361829 | 0.90 | IRAK4 (0.61) | IRAK4CHEK1CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL18427808 | 0.86 | IRAK4 (1.00) | IRAK4NPC1RAB9AMAPK1ATM | |
| SCHEMBL13818544 | 0.84 | IRAK4 (0.56) | IRAK4CHEK1 | |
| SCHEMBL13818547 | 0.82 | NPC1 (0.68) | IRAK4NPC1RAB9AMAPK1ATM | |
| SCHEMBL2140489 | 0.82 | NPC1 (0.77) | IRAK4NPC1RAB9AMAPK1ATM | |
| SCHEMBL16809297 | 0.82 | IRAK4 (0.78) | IRAK4NPC1RAB9AMAPK1ATM | |
| SCHEMBL2137688 | 0.81 | NPC1 (0.64) | IRAK4NPC1RAB9AMAPK1ATM | |
| SCHEMBL2140620 | 0.81 | IRAK4 (0.67) | IRAK4NPC1RAB9AMAPK1ATM | |
| SCHEMBL4349506 | 0.80 | IRAK4 (0.61) | IRAK4CHEK1CYP1A2 | |
| SCHEMBL4358006 | 0.80 | IRAK4 (0.61) | IRAK4ATMCHEK1TLR7HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070924-A1 | New 2 hetarylthiazol-4-carboxylic acid derivatives, their manufacture and use as medicine | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-06-17 | — | — | EP | claimed |
| EP-2070924-A1 | New 2 hetarylthiazol-4-carboxylic acid derivatives, their manufacture and use as medicine | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-06-17 | — | — | EP | disclosed |