Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.61 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.50 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.43 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4357829 | 0.90 | IRAK4 (0.75) | IRAK4CHEK1CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL4349506 | 0.89 | IRAK4 (0.61) | IRAK4CHEK1MAPKAPK2MAPTLMNA | |
| SCHEMBL13818544 | 0.84 | IRAK4 (0.56) | IRAK4CHEK1MAPT | |
| SCHEMBL4358006 | 0.81 | IRAK4 (0.61) | IRAK4CHEK1MAPTLMNAMEN1 | |
| SCHEMBL13818359 | 0.80 | IRAK4 (0.54) | IRAK4CHEK1MAPTLMNAMEN1 | |
| SCHEMBL13818339 | 0.77 | IRAK4 (0.54) | IRAK4CHEK1MAPT | |
| SCHEMBL14704286 | 0.77 | IRAK4 (0.56) | IRAK4CHEK1MAPTLMNAMEN1 | |
| SCHEMBL4357764 | 0.77 | IRAK4 (0.58) | IRAK4CHEK1MAPKAPK2MAPTLMNA | |
| SCHEMBL2138509 | 0.77 | CHEK1 (0.59) | IRAK4CHEK1MAPTLMNAMEN1 | |
| SCHEMBL2552448 | 0.77 | IRAK4 (0.60) | IRAK4MAPKAPK2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070924-A1 | New 2 hetarylthiazol-4-carboxylic acid derivatives, their manufacture and use as medicine | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-06-17 | — | — | EP | claimed |
| EP-2070924-A1 | New 2 hetarylthiazol-4-carboxylic acid derivatives, their manufacture and use as medicine | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-06-17 | — | — | EP | disclosed |