Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.61 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ATM | Q13315 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4349506 | 0.93 | IRAK4 (0.61) | IRAK4CHEK1LMNAHDAC3PIM1 | |
| SCHEMBL4357764 | 0.91 | IRAK4 (0.58) | IRAK4CHEK1LMNAHDAC3HDAC2 | |
| SCHEMBL13818341 | 0.88 | IRAK4 (0.55) | IRAK4CHEK1HDAC3HDAC2 | |
| SCHEMBL13818665 | 0.85 | IRAK4 (0.50) | IRAK4CHEK1HDAC3HDAC2HTR6 | |
| SCHEMBL4361829 | 0.81 | IRAK4 (0.61) | IRAK4CHEK1LMNAPIM1PIM3 | |
| SCHEMBL13818373 | 0.81 | IRAK4 (0.53) | IRAK4CHEK1HDAC3HDAC2 | |
| SCHEMBL2080467 | 0.80 | CHEK1 (0.55) | IRAK4CHEK1LMNATDP1MAPT | |
| SCHEMBL4357829 | 0.80 | IRAK4 (0.75) | IRAK4CHEK1HDAC2TLR7ATM | |
| SCHEMBL13818544 | 0.79 | IRAK4 (0.56) | IRAK4CHEK1MAPT | |
| SCHEMBL18427815 | 0.78 | TDP1 (0.65) | IRAK4CHEK1LMNATDP1TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070916-A1 | 2-Arylthiazol-4-carboxylic acid derivatives, their manufacture and use as medicine | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-06-17 | — | — | EP | claimed |
| EP-2070916-A1 | 2-Arylthiazol-4-carboxylic acid derivatives, their manufacture and use as medicine | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-06-17 | — | — | EP | disclosed |
| EP-2070916-A1 | 2-Arylthiazol-4-carboxylic acid derivatives, their manufacture and use as medicine | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-06-17 | — | — | EP | disclosed |