Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.56 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.56 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.49 |
| ▸ | FBP1 | P09467 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | INSR | P06213 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | FLT4 | P35916 | 1/20 | 0.48 |
| ▸ | CLK1 | P49759 | 1/20 | 0.48 |
| ▸ | TEK | Q02763 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8571074 | 0.88 | GRM1 (0.54) | EGFRERBB2ERBB4GRM1FBP1 | |
| SCHEMBL8565015 | 0.84 | EGFR (0.66) | EGFRERBB2ERBB4GRM1FBP1 | |
| SCHEMBL4353234 | 0.81 | EGFR (0.70) | EGFRERBB2ERBB4GRM1MAPT | |
| SCHEMBL8567062 | 0.80 | EGFR (0.56) | EGFRERBB2ERBB4GRM1FBP1 | |
| SCHEMBL4350714 | 0.80 | GRM1 (0.62) | EGFRERBB2ERBB4GRM1FBP1 | |
| SCHEMBL28411490 | 0.77 | EGFR (0.60) | EGFRERBB2ERBB4GRM1FBP1 | |
| SCHEMBL8562436 | 0.75 | EGFR (0.68) | EGFRERBB2ERBB4GRM1FBP1 | |
| SCHEMBL8488091 | 0.75 | EGFR (0.67) | EGFRERBB2ERBB4GRM1MAPT | |
| SCHEMBL8486556 | 0.75 | EGFR (0.53) | EGFRERBB2ERBB4KDRMAPT | |
| SCHEMBL8569737 | 0.73 | EGFR (0.53) | EGFRERBB2ERBB4GRM1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070328-A1 | MODULATORS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) PATHWAY FOR USE IN THE TREATMENT OR PREVENTION OF SUBSTANCE ABUSE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-06-04 | — | — | WO | disclosed |