Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.56 |
| ▸ | FBP1 | P09467 | 2/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | INSR | P06213 | 1/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.56 |
| ▸ | FLT4 | P35916 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | CLK1 | P49759 | 1/20 | 0.56 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.56 |
| ▸ | TEK | Q02763 | 1/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.56 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.54 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28407489 | 0.88 | EGFR (0.76) | EGFRERBB2FBP1AURKAINSR | |
| SCHEMBL7475167 | 0.87 | EGFR (0.51) | EGFR | |
| SCHEMBL7473037 | 0.83 | SRC (0.49) | EGFRERBB2PDGFRBKDR | |
| SCHEMBL28397062 | 0.82 | EGFR (0.68) | EGFRERBB2ERBB4 | |
| SCHEMBL28182145 | 0.81 | EGFR (0.51) | EGFRERBB2FBP1AURKAINSR | |
| SCHEMBL28403915 | 0.81 | EGFR (0.74) | EGFRERBB2FBP1AURKAINSR | |
| SCHEMBL28181388 | 0.80 | EGFR (0.56) | EGFRERBB2FBP1AURKAPDGFRB | |
| SCHEMBL7469491 | 0.77 | HTT (0.56) | AURKAAURKB | |
| SCHEMBL4358041 | 0.77 | EGFR (0.56) | EGFRERBB2FBP1AURKAINSR | |
| SCHEMBL29731422 | 0.76 | EGFR (0.98) | EGFRERBB2FLT4KDREPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107200715-B | Quinazoline derivative and application thereof in preparation of antitumor drugs | 陕西师范大学 | 2020-05-29 | — | — | CN | claimed |
| CN-107200715-B | Quinazoline derivative and application thereof in preparation of antitumor drugs | 陕西师范大学 | 2020-05-29 | — | — | CN | disclosed |