SCHEMBL435880

SCHEMBL435880

Cc1[nH]n(-c2ccccc2)c(=O)c1C=O

nearest known ligand 0.68

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.68
KMT2A Q03164 3/20 0.68
HTT P42858 3/20 0.68
MAPT P10636 8/20 0.61
GAA P10253 3/20 0.61
MAPK1 P28482 3/20 0.61
TDP1 Q9NUW8 2/20 0.61
KDM4E B2RXH2 6/20 0.59
SMN1; SMN2 Q16637 3/20 0.59
ALDH1A1 P00352 2/20 0.59
RAB9A P51151 1/20 0.59
ALOX15 P16050 1/20 0.58
CYP2C9 P11712 1/20 0.57
LMNA P02545 1/20 0.57
TP53 P04637 1/20 0.57
XBP1 P17861 1/20 0.57
NPSR1 Q6W5P4 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2449607 0.86 MEN1 (0.68) MEN1KMT2AHTTMAPTGAA
SCHEMBL10436991 0.86 MAPT (0.57) MEN1KMT2AHTTMAPTGAA
SCHEMBL11685795 0.83 LMNA (0.57) MEN1KMT2AHTTMAPTGAA
SCHEMBL11688590 0.80 MEN1 (0.46) MEN1KMT2AHTTMAPTGAA
SCHEMBL11687030 0.79 ALDH1A1 (0.53) MEN1KMT2AHTTMAPTGAA
SCHEMBL2558964 0.79 MEN1 (0.58) MEN1KMT2AHTTMAPTGAA
SCHEMBL11335663 0.78 MEN1 (0.48) MEN1KMT2AHTTMAPTGAA
SCHEMBL4324454 0.78 GAA (0.66) MEN1KMT2AHTTMAPTGAA
SCHEMBL11687499 0.77 KMT2A (0.49) MEN1KMT2AHTTMAPTGAA
SCHEMBL28770327 0.76 ALDH1A1 (0.51) MEN1KMT2AHTTMAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
WO-2012010918-A2 OPTICAL DEVICES MEDICONTUR ORVOSTECHNIKAI KFT. (HU) 2012-01-26 WO disclosed
US-4979962-A Using chromium complex in betaine form BASF AKTIENGESELLSCHAFT (DE) 1990-12-25 US disclosed
EP-0354178-A1 Thermoplastics containing a metal complex pigment CIBA-GEIGY AG (CH) 1990-02-07 EP disclosed
CN-1038138-A The colouring method of natural or synthesizing polyamides BASF AG (DE) 1989-12-20 CN disclosed
EP-0344560-A2 Process for dyeing natural or synthetic polyamides BASF Aktiengesellschaft (DE) 1989-12-06 EP disclosed
US-4460768-A Nickel complex pigments of azines CIBA-GEIGY CORPORATION (US) 1984-07-17 US disclosed
EP-0020299-B1 NICKEL COMPLEXES OF AZINES, THEIR PREPARATION PROCESS, PIGMENTING PROCESS FOR A HIGH MOLECULAR ORGANIC MATERIAL AND THE MATERIAL SO OBTAINED CIBA-GEIGY AG (CH) 1983-02-09 EP disclosed
US-4355159-A Nickel complex pigments of azines CIBA-GEIGY CORPORATION (US) 1982-10-19 US disclosed
US-4264494-A Chromium complex dyestuffs for natural polyamides and synthetic nylons BASF AKTIENGESELLSCHAFT (DE) 1981-04-28 US disclosed
US-4024132-A Azomethine pigments CIBA-GEIGY CORPORATION (US) 1977-05-17 US disclosed
US-4016157-A COLORING PLASTICS AND LACQUERS CIBA-GEIGY CORPORATION (US) 1977-04-05 US disclosed
US-3975382-A PYRAZOLONE(5)METAL COMPLEXES AS STABILIZERS FOR ORGANIC MATERIALSULTRAVIOLET RADIATION SANDOZ LTD. (CH) 1976-08-17 US disclosed
US-3974149-A TONERS CIBA-GEIGY CORPORATION (US) 1976-08-10 US disclosed