Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 15/20 | 0.79 |
| ▸ | EGFR | P00533 | 13/20 | 0.70 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.53 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.53 |
| ▸ | ROS1 | P08922 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.53 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.53 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.46 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005564 | 0.89 | ERBB2 (1.00) | ERBB2EGFRAURKBERBB4CHEK2 | |
| SCHEMBL7010246 | 0.88 | ERBB2 (0.72) | ERBB2EGFRAURKBERBB4CHEK2 | |
| Hydrochloric Acid SCHEMBL7013332 | 0.88 | ERBB2 (0.98) | ERBB2EGFRAURKBERBB4CHEK2 | |
| SCHEMBL7007882 | 0.88 | ERBB2 (0.76) | ERBB2EGFR | |
| SCHEMBL27518939 | 0.85 | ERBB2 (0.78) | ERBB2EGFRAURKBERBB4CHEK2 | |
| SCHEMBL4559023 | 0.84 | ERBB2 (0.72) | ERBB2EGFRAURKBERBB4CHEK2 | |
| SCHEMBL7909698 | 0.83 | ERBB2 (0.75) | ERBB2EGFRAURKBERBB4CHEK2 | |
| SCHEMBL7005311 | 0.83 | ERBB2 (1.00) | ERBB2EGFRAURKBERBB4CHEK2 | |
| SCHEMBL7890178 | 0.83 | ERBB2 (0.77) | ERBB2EGFRAURKBERBB4CHEK2 | |
| SCHEMBL7007362 | 0.83 | ERBB2 (1.00) | ERBB2EGFRAURKBERBB4CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1230185-A | Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors | GLAXO GROUP LTD (GB) | 1999-09-29 | — | — | CN | claimed |
| WO-2009070328-A1 | MODULATORS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) PATHWAY FOR USE IN THE TREATMENT OR PREVENTION OF SUBSTANCE ABUSE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-06-04 | — | — | WO | disclosed |