Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NAAA | Q02083 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ASPH | Q12797 | 1/20 | 0.32 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11838973 | 0.85 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3TP53RECQL | |
| SCHEMBL3534847 | 0.84 | ESR2 (0.39) | ESR2SLC6A2SLC6A4SLC6A3TP53 | |
| SCHEMBL11754963 | 0.79 | PTGDR2 (0.42) | SLC6A2SLC6A4SLC6A3ALDH1A1NAAA | |
| SCHEMBL28184636 | 0.79 | HRH1 (0.38) | ESR2SLC6A2SLC6A4SLC6A3IKBKB | |
| SCHEMBL27267184 | 0.78 | ESR2 (0.47) | ESR2TP53RECQLIKBKBALDH1A1 | |
| SCHEMBL504941 | 0.76 | TP53 (0.61) | ESR2SLC6A3TP53RECQLALDH1A1 | |
| SCHEMBL27735857 | 0.73 | NAAA (0.47) | ESR2SLC6A2SLC6A4SLC6A3IKBKB | |
| SCHEMBL28223040 | 0.72 | IKBKB (0.41) | ESR2SLC6A2SLC6A4SLC6A3TP53 | |
| SCHEMBL14458709 | 0.72 | L3MBTL1 (0.46) | ALDH1A1TSHRKMT2AKDM4EHTT | |
| SCHEMBL6953228 | 0.72 | HCAR2 (0.43) | ESR2SLC6A2SLC6A4SLC6A3ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009091433-A2 | SPIRO AND DISPIRO 1,2,4-TRIOXOLANE ANTIMALARIALS | MEDICINES FOR MALARIA VENTURE MMV (CH) | 2009-07-23 | — | — | WO | disclosed |
| US-20080125441-A1 | SPIRO AND DISPIRO 1,2,4-TRIOXOLANE ANTIMALARIALS | MEDICINES FOR MALARIA VENTURE MMV (CH) | 2008-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080125441-A1 | SPIRO AND DISPIRO 1,2,4-TRIOXOLANE ANTIMALARIALS | DHODH, THPO, SQLE | ESR2 1687/4885SLC6A2 3142/4885SLC6A4 3458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.