Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN3 | Q9H6Z9 | 10/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | EGLN1 | Q9GZT9 | 11/20 | 0.47 |
| ▸ | EGLN2 | Q96KS0 | 6/20 | 0.47 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4359892 | 0.89 | EGLN3 (0.59) | EGLN3EGLN1EGLN2CYSLTR2PTGDR2 | |
| SCHEMBL4362443 | 0.88 | EGLN3 (0.52) | EGLN3EGLN1EGLN2CYSLTR2PTGDR2 | |
| SCHEMBL3846940 | 0.86 | EGLN3 (0.72) | EGLN3KMT2AEGLN1EGLN2CYSLTR2 | |
| SCHEMBL4371854 | 0.85 | EGLN3 (0.54) | EGLN3EGLN1EGLN2CYSLTR2LMNA | |
| SCHEMBL3857686 | 0.84 | EGLN3 (0.93) | EGLN3KMT2AEGLN1EGLN2CYSLTR2 | |
| SCHEMBL3850392 | 0.83 | EGLN3 (0.69) | EGLN3KMT2AEGLN1EGLN2CYSLTR2 | |
| SCHEMBL3847025 | 0.82 | EGLN3 (0.86) | EGLN3KMT2AEGLN1EGLN2CYSLTR2 | |
| SCHEMBL4359069 | 0.82 | EGLN3 (0.51) | EGLN3EGLN1EGLN2 | |
| SCHEMBL4363082 | 0.82 | EGLN3 (0.51) | EGLN3KMT2AEGLN1EGLN2LMNA | |
| SCHEMBL3851851 | 0.81 | EGLN3 (1.00) | EGLN3KMT2AEGLN1EGLN2CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124565-A2 | N-SUBSTITUTED GLYCINE DERIVATIVES: HYDROXYLASE INHIBITORS | Smithkline Beecham Corporation (US) | 2009-12-02 | — | — | EP | claimed |
| WO-2008089052-A2 | N-SUBSTITUTED GLYCINE DERIVATIVES: HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-24 | — | — | WO | claimed |