Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN3 | Q9H6Z9 | 5/20 | 0.51 |
| ▸ | EGLN1 | Q9GZT9 | 9/20 | 0.39 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM6B | O15054 | 1/20 | 0.38 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.38 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4368360 | 0.88 | EGLN3 (0.41) | EGLN3EGLN1KDM6BFTOHIF1AN | |
| SCHEMBL4371854 | 0.87 | EGLN3 (0.54) | EGLN3EGLN1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL3853842 | 0.85 | EGLN3 (0.52) | EGLN3EGLN1P2RY14LMNAHTT | |
| SCHEMBL4359892 | 0.85 | EGLN3 (0.59) | EGLN3EGLN1EGLN2 | |
| SCHEMBL4362443 | 0.84 | EGLN3 (0.52) | EGLN3EGLN1EGLN2 | |
| SCHEMBL4359069 | 0.84 | EGLN3 (0.51) | EGLN3EGLN1EGLN2 | |
| SCHEMBL4359785 | 0.82 | EGLN3 (0.68) | EGLN3EGLN1LMNAMAPTKMT2A | |
| SCHEMBL4363076 | 0.81 | EGLN1 (0.41) | EGLN3EGLN1HTTEGLN2L3MBTL1 | |
| SCHEMBL4365040 | 0.80 | EGLN3 (0.48) | EGLN3EGLN1 | |
| SCHEMBL4357034 | 0.80 | EGLN3 (0.49) | EGLN3EGLN1LMNAHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124565-A2 | N-SUBSTITUTED GLYCINE DERIVATIVES: HYDROXYLASE INHIBITORS | Smithkline Beecham Corporation (US) | 2009-12-02 | — | — | EP | claimed |
| WO-2008089052-A2 | N-SUBSTITUTED GLYCINE DERIVATIVES: HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-24 | — | — | WO | claimed |