Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8403513 | 0.68 | TSHR (0.48) | L3MBTL1POLBSMN1; SMN2TSHR | |
| SCHEMBL10193164 | 0.67 | SIGMAR1 (0.50) | L3MBTL1MPOTSHR | |
| SCHEMBL3706008 | 0.67 | SLC6A3 (0.33) | — | |
| SCHEMBL9200075 | 0.65 | TSHR (0.46) | L3MBTL1POLBSMN1; SMN2TSHR | |
| SCHEMBL28865925 | 0.65 | POLB (0.44) | L3MBTL1POLBSMN1; SMN2TSHR | |
| SCHEMBL20288417 | 0.65 | CNR2 (0.33) | — | |
| SCHEMBL4371812 | 0.65 | — | — | |
| SCHEMBL15114076 | 0.64 | TSHR (0.48) | L3MBTL1POLBSMN1; SMN2TSHR | |
| SCHEMBL1237730 | 0.64 | PDE2A (0.39) | — | |
| SCHEMBL10198685 | 0.64 | TSHR (0.52) | L3MBTL1POLBSMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2458991-A1 | RADIOLABELED CGRP ANTAGONISTS | Merck Sharp & Dohme Corp. (US) | 2012-06-06 | — | — | EP | disclosed |
| WO-2009120652-A2 | MONOCYCLIC CGRP RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2009-10-01 | — | — | WO | disclosed |