Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4222561 | 0.79 | CDK4 (0.41) | BTK | |
| SCHEMBL30968152 | 0.79 | PDE2A (0.39) | BTKKDM4EALDH1A1KMT2A | |
| SCHEMBL4262449 | 0.76 | KDM4E (0.33) | KDM4EMEN1MAPTKMT2A | |
| SCHEMBL31737850 | 0.72 | MERTK (0.55) | MEN1MAPK1KMT2A | |
| SCHEMBL31737805 | 0.72 | ALDH1A1 (0.48) | MEN1ALDH1A1MAPK1KMT2A | |
| SCHEMBL31738236 | 0.67 | LRRK2 (0.48) | MAPK1 | |
| SCHEMBL31738251 | 0.67 | IGF1R (0.43) | BTKMAPK1 | |
| SCHEMBL31633020 | 0.66 | MAT2A (0.33) | — | |
| SCHEMBL22553976 | 0.64 | HSD17B10 (0.42) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL31633155 | 0.61 | ADORA2A (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2026811-A1 | PYRAZOLO [3, 4-D]PYRIMIDINE DERIVATIVES USEFUL TO TREAT RESPIRATORY DISORDERS | Novartis AG (CH) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007134828-A1 | PYRAZOLO [3, 4-D] PYRIMIDINE DERIVATIVES USEFUL TO TREAT RESPIRATORY DISORDERS | NOVARTIS AG (CH) | 2007-11-29 | — | — | WO | disclosed |