Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 14/20 | 0.62 |
| ▸ | MET | P08581 | 7/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1472355 | 0.84 | AXL (0.61) | AXLMETKDR | |
| SCHEMBL4367074 | 0.83 | MET (0.60) | AXLMETKDR | |
| SCHEMBL1471802 | 0.83 | KDR (0.60) | AXLMETKDR | |
| SCHEMBL1472502 | 0.81 | AXL (0.62) | AXLMETKDR | |
| SCHEMBL4370858 | 0.80 | PDGFRA (0.56) | AXLMETKDR | |
| SCHEMBL372095 | 0.78 | MET (0.68) | METKDR | |
| SCHEMBL372064 | 0.78 | MET (0.69) | AXLMETKDR | |
| SCHEMBL407686 | 0.78 | MET (0.60) | AXLMETKDR | |
| SCHEMBL29693546 | 0.78 | MET (0.60) | AXLMETKDR | |
| SCHEMBL12075210 | 0.77 | MAPT (0.54) | AXLMETKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125780-A1 | SUBSTITUTED HETEROCYCLES AND METHODS OF USE | Amgen Inc. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079294-A1 | SUBSTITUTED HETEROCYCLES AND METHODS OF USE | AMGEN INC. (US) | 2008-07-03 | — | — | WO | disclosed |