Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.49 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.49 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.49 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29054929 | 0.86 | MDM2 (0.57) | MDM2L3MBTL1KDM4EMEN1KMT2A | |
| SCHEMBL13600207 | 0.84 | TSHR (0.64) | MEN1KMT2AMAPTNPC1TP53 | |
| SCHEMBL26623072 | 0.81 | MDM2 (0.52) | MDM2L3MBTL1KDM4EMEN1KMT2A | |
| SCHEMBL14571967 | 0.81 | MDM2 (0.61) | MDM2L3MBTL1KDM4EMEN1KMT2A | |
| SCHEMBL334744 | 0.79 | L3MBTL1 (0.72) | MDM2L3MBTL1KDM4ETAAR1CA12 | |
| SCHEMBL20870704 | 0.79 | EPHX2 (0.70) | MEN1KMT2ACA12CA1CA2 | |
| SCHEMBL2862896 | 0.79 | MDM2 (0.59) | MDM2L3MBTL1KDM4EMEN1KMT2A | |
| SCHEMBL474941 | 0.78 | HDAC1 (0.65) | L3MBTL1MEN1KMT2ACA12CA1 | |
| SCHEMBL11646619 | 0.77 | ALDH1A1 (0.64) | MEN1KMT2ACA9MAPT | |
| SCHEMBL22920041 | 0.77 | L3MBTL1 (0.60) | L3MBTL1KDM4EMEN1KMT2ATAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3085697-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF USING THE SAME | Incyte Holdings Corporation (US) | 2016-10-26 | — | — | EP | disclosed |
| US-7618978-B2 | Amides as BACE inhibitors | ELI LILLY AND COMPANY (US) | 2009-11-17 | — | — | US | disclosed |
| US-20070225372-A1 | Amides as Bace Inhibitors | ELI LILLY AND COMPANY | 2007-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225372-A1 | Amides as Bace Inhibitors | BACE2, BACE1, APP | MDM2 2107/4885L3MBTL1 4137/4885KDM4E 453/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.