Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.68 |
| ▸ | RAB9A | P51151 | 4/20 | 0.68 |
| ▸ | PKM | P14618 | 1/20 | 0.68 |
| ▸ | ACHE | P22303 | 1/20 | 0.59 |
| ▸ | BACE1 | P56817 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | APP | P05067 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL43662 | 1.00 | NPC1 (0.68) | NPC1RAB9APKMACHEBACE1 | |
| SCHEMBL43454 | 0.85 | ACHE (0.53) | NPC1RAB9APKMACHEBACE1 | |
| SCHEMBL43090 | 0.85 | ACHE (0.53) | NPC1RAB9APKMACHEBACE1 | |
| SCHEMBL43091 | 0.85 | ACHE (0.53) | NPC1RAB9APKMACHEBACE1 | |
| SCHEMBL42173 | 0.85 | NPC1 (0.75) | NPC1RAB9APKMACHEBACE1 | |
| SCHEMBL42247 | 0.82 | NPC1 (0.68) | NPC1RAB9APKMACHEBACE1 | |
| SCHEMBL43690 | 0.81 | NPC1 (0.64) | NPC1RAB9APKMACHEBACE1 | |
| SCHEMBL42168 | 0.80 | ACHE (0.49) | RAB9AACHEBACE1ALDH1A1POLB | |
| SCHEMBL42309 | 0.80 | ACHE (0.49) | RAB9AACHEBACE1ALDH1A1POLB | |
| SCHEMBL46987 | 0.80 | ACHE (0.49) | RAB9AACHEBACE1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2484664-B1 | Cyclic amine-1-carboxylic acid ester derivative and pharmaceutical composition containing the same | DAINIPPON SUMITOMO PHARMA CO (JP) | 2013-09-04 | — | — | EP | disclosed |
| US-8367835-B2 | Cyclic amine-1-carboxylic acid ester derivative and pharmaceutical composition containing the same | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2013-02-05 | — | — | US | disclosed |
| EP-2484664-A1 | Cyclic amine-1-carboxylic acid ester derivative and pharmaceutical composition containing the same | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2012-08-08 | — | — | EP | disclosed |
| US-20120028937-A1 | CYCLIC AMINE-1-CARBOXYLIC ACID ESTER DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2012-02-02 | — | — | US | disclosed |
| EP-2277861-A1 | CYCLIC AMINE-1-CARBOXYLIC ACID ESTER DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2011-01-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028937-A1 | CYCLIC AMINE-1-CARBOXYLIC ACID ESTER DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | HRH3, ARG1, CNR1 | NPC1 2291/4885RAB9A 1528/4885PKM 1800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.