Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 10/20 | 0.71 |
| ▸ | AURKB | Q96GD4 | 10/20 | 0.71 |
| ▸ | GSK3A | P49840 | 9/20 | 0.71 |
| ▸ | GSK3B | P49841 | 9/20 | 0.71 |
| ▸ | CDC42BPA | Q5VT25 | 9/20 | 0.71 |
| ▸ | CSNK1G3 | Q9Y6M4 | 9/20 | 0.71 |
| ▸ | CHEK2 | O96017 | 8/20 | 0.71 |
| ▸ | PRKACA | P17612 | 7/20 | 0.71 |
| ▸ | RPS6KB1 | P23443 | 7/20 | 0.71 |
| ▸ | RPS6KA3 | P51812 | 7/20 | 0.71 |
| ▸ | PKN2 | Q16513 | 7/20 | 0.71 |
| ▸ | CHEK1 | O14757 | 7/20 | 0.71 |
| ▸ | PRKG1 | Q13976 | 6/20 | 0.71 |
| ▸ | HIPK4 | Q8NE63 | 6/20 | 0.71 |
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.71 |
| ▸ | SGK2 | Q9HBY8 | 5/20 | 0.71 |
| ▸ | AKT1 | P31749 | 5/20 | 0.71 |
| ▸ | STK17A | Q9UEE5 | 5/20 | 0.71 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.71 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4370957 | 0.84 | ROCK1 (0.67) | ROCK1AURKBGSK3AGSK3BCDC42BPA | |
| SCHEMBL4375983 | 0.80 | MAPKAPK2 (1.00) | ROCK1AURKBGSK3AGSK3BCDC42BPA | |
| SCHEMBL4376451 | 0.77 | MAPKAPK2 (0.85) | ROCK1AURKBGSK3AGSK3BCDC42BPA | |
| SCHEMBL4374703 | 0.77 | ROCK1 (1.00) | ROCK1AURKBGSK3AGSK3BCDC42BPA | |
| SCHEMBL4366366 | 0.77 | ROCK1 (1.00) | ROCK1AURKBGSK3AGSK3BCDC42BPA | |
| SCHEMBL4366437 | 0.76 | MAPKAPK2 (0.68) | ROCK1AURKBGSK3AGSK3BCDC42BPA | |
| SCHEMBL4366308 | 0.76 | ROCK1 (0.71) | ROCK1AURKBGSK3AGSK3BCDC42BPA | |
| SCHEMBL4375317 | 0.73 | GSK3B (0.72) | ROCK1AURKBGSK3AGSK3BCDC42BPA | |
| SCHEMBL4371411 | 0.73 | ROCK1 (0.72) | ROCK1AURKBGSK3AGSK3BCDC42BPA | |
| SCHEMBL4370137 | 0.73 | AURKB (0.76) | ROCK1AURKBGSK3AGSK3BCDC42BPA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009012375-A2 | SQUARATE KINASE INHIBITORS | WYETH (US) | 2009-01-22 | — | — | WO | claimed |
| WO-2009012375-A2 | SQUARATE KINASE INHIBITORS | WYETH (US) | 2009-01-22 | — | — | WO | disclosed |