SCHEMBL4366767

SCHEMBL4366767

COc1cc(C=Cc2ccc(OC)cc2OC)cc(OC)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 17/20 1.00
CYP1A1 P04798 17/20 1.00
CYP1B1 Q16678 17/20 1.00
CYP3A4 P08684 2/20 1.00
CYP2C19 P33261 2/20 1.00
CYP2E1 P05181 1/20 1.00
CYP2C8 P10632 1/20 1.00
CYP2D6 P10635 1/20 1.00
CYP2A6 P11509 1/20 1.00
CYP2C9 P11712 1/20 1.00
CYP4B1 P13584 1/20 1.00
CYP2B6 P20813 1/20 1.00
CYP3A5 P20815 1/20 1.00
CYP2A7 P20853 1/20 1.00
CYP3A7 P24462 1/20 1.00
CYP2F1 P24903 1/20 1.00
CYP2C18 P33260 1/20 1.00
CYP2J2 P51589 1/20 1.00
CYP4F2 P78329 1/20 1.00
CYP4F8 P98187 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30090378 1.00 CYP1A2 (1.00) CYP1A2CYP1A1CYP1B1CYP3A4CYP2C19
SCHEMBL17675325 1.00 CYP1A2 (1.00) CYP1A2CYP1A1CYP1B1CYP3A4CYP2C19
SCHEMBL4366766 1.00 CYP1A2 (1.00) CYP1A2CYP1A1CYP1B1CYP3A4CYP2C19
SCHEMBL25706432 0.89 CYP1A2 (1.00) CYP1A2CYP1A1CYP1B1CYP3A4CYP2C19
SCHEMBL5495431 0.87 CYP1A2 (1.00) CYP1A2CYP1A1CYP1B1CYP3A4CYP2C19
SCHEMBL5495428 0.87 CYP1A2 (1.00) CYP1A2CYP1A1CYP1B1CYP3A4CYP2C19
Resveratrol SCHEMBL9273945 0.87 CYP1A1 (0.76) CYP1A2CYP1A1CYP1B1CYP3A4CYP2C19
SCHEMBL15288712 0.86 CYP1A2 (1.00) CYP1A2CYP1A1CYP1B1CYP3A4CYP2C19
SCHEMBL15288715 0.86 CYP1A2 (1.00) CYP1A2CYP1A1CYP1B1CYP3A4CYP2C19
SCHEMBL15781554 0.85 CYP1A2 (0.73) CYP1A2CYP1A1CYP1B1CYP3A4CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240269066-A1 USE OF CYP450 INHIBITOR IN INHIBITING OR KILLING MITES AND TREATING XEROPHTHALMIA PRECVISION BIOTECHNOLOGIES LTD. (CN) 2024-08-15 US claimed
EP-4353264-A1 USE OF CYP450 INHIBITOR IN INHIBITING OR KILLING MITES AND TREATING DRY EYE SYNDROME Precvision Biotechnologies Ltd. (CN) 2024-04-17 EP claimed
CN-117561081-A Application of CYP450 inhibitor in inhibiting or killing mites and treating xerophthalmia 广州珍实视界生物医药科技有限公司 2024-02-13 CN claimed
US-20230033047-A1 Estrogen Metabolite Levels And Cancer Driver Gene Mutations In Lung Cancer Risk Stratification And Treatment INSTITUTE FOR CANCER RESEARCH D/B/A THE RESEARCH INSTITUTE OF FOX CHASE CANCER CENTER 2023-02-02 US claimed
WO-2022257986-A1 USE OF CYP450 INHIBITOR IN INHIBITING OR KILLING MITES AND TREATING DRY EYE SYNDROME 广州岐微生物医药科技有限公司 2022-12-15 WO claimed
EP-4087660-A1 ESTROGEN METABOLITE LEVELS AND CANCER DRIVER GENE MUTATIONS IN LUNG CANCER RISK STRATIFICATION AND TREATMENT Institute For Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center (US) 2022-11-16 EP claimed
WO-2021142408-A1 ESTROGEN METABOLITE LEVELS AND CANCER DRIVER GENE MUTATIONS IN LUNG CANCER RISK STRATIFICATION AND TREATMENT INSTITUTE FOR CANCER RESEARCH D/B/A THE RESEARCH INSTITUTE OF FOX CHASE CANCER CENTER (US) 2021-07-15 WO claimed
US-20190209618-A1 METHODS AND COMPOSITIONS FOR EXPANSION OF HEMATOPOIETIC STEM AND/OR PROGENITOR CELLS EMPLOYING A CYTOCHROME P450 1B1 (CYP1B1) INHIBITOR OR A MUSASHI-2 (MSI2) ACTIVATOR MCMASTER UNIVERSITY (CA) 2019-07-11 US claimed
WO-2017185179-A1 METHODS AND COMPOSITIONS FOR EXPANSION OF HEMATOPOIETIC STEM AND/OR PROGENITOR CELLS EMPLOYING A CYTOCHROME P450 1B1 (CYP1B1) INHIBITOR OR A MUSASHI-2 (MSI2) ACTIVATOR MCMASTER UNIVERSITY (CA) 2017-11-02 WO claimed
WO-2009001046-A2 [11C]METHOXY-RADIOLABELLED 2,3',4,5'-TETRAMETHYLSTILBENE (TMS) AND ITS PREPARATION AND USE THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN (GB) 2008-12-31 WO claimed
US-12448437-B2 Transplant tolerance induction with carbodiimide treated tolerizing vaccine REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 2025-10-21 US disclosed
WO-2025101983-A1 NON-STEROIDAL ISONITRILE BINDING COMPOUNDS OF CYTOCHROME P450 SUBTYPES BRANDEIS UNIVERSITY (US) 2025-05-15 WO disclosed
EP-4417212-A2 TRANSPLANT TOLERANCE INDUCTION WITH CARBODIIMIDE TREATED TOLERIZING VACCINE REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 2024-08-21 EP disclosed
EP-3866815-B1 TRANSPLANT TOLERANCE INDUCTION WITH CARBODIIMIDE TREATED TOLERIZING VACCINE UNIV MINNESOTA (US) 2024-05-01 EP disclosed
CN-117561081-A Application of CYP450 inhibitor in inhibiting or killing mites and treating xerophthalmia 广州珍实视界生物医药科技有限公司 2024-02-13 CN disclosed
WO-2009001046-A2 [11C]METHOXY-RADIOLABELLED 2,3',4,5'-TETRAMETHYLSTILBENE (TMS) AND ITS PREPARATION AND USE THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN (GB) 2008-12-31 WO disclosed
US-20070276172-A1 Single step microwave induced process for the preparation of substituted stilbenes and its analogs COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2007-11-29 US disclosed
WO-2007110883-A1 A SINGLE STEP MICROWAVE INDUCED PROCESS FOR THE PREPARATION OF SUBSTITUTED STILBENES AND ITS ANALOGS COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2007-10-04 WO disclosed
US-7253324-B1 Process for the synthesis of biologically active oxygenated compounds by dealkylation of the corresponding alkylethers SAMI LABS LIMITED (IN) 2007-08-07 US disclosed
WO-2003018013-A1 STILBENE DERIVATIVE HAVING CYTOCHROME P450 1B1 INHIBITORY ACTIVITY, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, METHOD FOR PREPARING THE SAME, AND COMPOSITION INCLUDING THE SAME PROMEDITECH, INC. (KR) 2003-03-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070276172-A1 Single step microwave induced process for the preparation of substituted stilbenes and its analogs HRH3, HPD, TET2 CYP1A2 2162/4885CYP1A1 1101/4885CYP1B1 1452/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.