Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.37 |
| ▸ | HNF4A | P41235 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MYC | P01106 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.34 |
| ▸ | DHODH | Q02127 | 3/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL436000 | 0.74 | PARP1 (0.44) | PARP1HNF4AALDH1A1L3MBTL1MYC | |
| SCHEMBL20510040 | 0.71 | PARP1 (0.73) | PARP1HNF4AALDH1A1L3MBTL1MYC | |
| SCHEMBL11094419 | 0.69 | PARP1 (0.49) | PARP1ALBALDH1A1MAPTHSD17B10 | |
| SCHEMBL14937360 | 0.64 | PARP1 (0.41) | PARP1HNF4AALDH1A1L3MBTL1MYC | |
| SCHEMBL6836766 | 0.63 | PARP1 (0.51) | PARP1HNF4AALDH1A1L3MBTL1MYC | |
| SCHEMBL20509570 | 0.63 | PARP1 (0.37) | PARP1ALBNPC1NOTUM | |
| SCHEMBL16401466 | 0.62 | MYC (0.61) | ALBHNF4AALDH1A1L3MBTL1MYC | |
| SCHEMBL31491647 | 0.62 | ALB (0.47) | ALBALDH1A1NPC1RAB9AHSD17B10 | |
| SCHEMBL19923221 | 0.61 | HSD17B10 (0.59) | ALBHNF4AALDH1A1L3MBTL1MYC | |
| SCHEMBL69716 | 0.60 | ALDH1A1 (0.69) | ALBHNF4AALDH1A1L3MBTL1MYC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595988-A1 | TRICYCLIC COMPOUNDS AND METHDS OF MAKING AND USING SAME | Zafgen, Inc. (US) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012012642-A1 | TRICYCLIC COMPOUNDS AND METHDS OF MAKING AND USING SAME | ZAFGEN CORPORATION (US) | 2012-01-26 | — | — | WO | disclosed |