Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HNF4A | P41235 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MYC | P01106 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALB | P02768 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | LIG1 | P18858 | 1/20 | 0.32 |
| ▸ | TYMS | P04818 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.30 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.30 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL436000 | 0.68 | PARP1 (0.44) | HSD17B10HNF4AALDH1A1L3MBTL1LMNA | |
| SCHEMBL14937360 | 0.66 | PARP1 (0.41) | HSD17B10HNF4AALDH1A1L3MBTL1LMNA | |
| SCHEMBL27316600 | 0.64 | CYP2C9 (0.41) | HSD17B10ALDH1A1MYCMAPTALB | |
| SCHEMBL28290216 | 0.62 | MYC (0.49) | HNF4AALDH1A1L3MBTL1LMNAMYC | |
| SCHEMBL29442138 | 0.60 | KDM4C (0.52) | ALDH1A1LMNAALOX15POLBHPGD | |
| SCHEMBL340702 | 0.60 | KDM4C (0.52) | ALDH1A1LMNAALOX15POLBHPGD | |
| SCHEMBL19923221 | 0.59 | HSD17B10 (0.59) | HSD17B10HNF4AALDH1A1L3MBTL1LMNA | |
| SCHEMBL28565062 | 0.59 | MYC (0.53) | HSD17B10HNF4AALDH1A1L3MBTL1LMNA | |
| SCHEMBL63603 | 0.58 | HSD17B10 (0.58) | HSD17B10HNF4AALDH1A1L3MBTL1LMNA | |
| SCHEMBL70265 | 0.58 | ALDH1A1 (0.63) | HSD17B10HNF4AALDH1A1L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595988-A1 | TRICYCLIC COMPOUNDS AND METHDS OF MAKING AND USING SAME | Zafgen, Inc. (US) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012012642-A1 | TRICYCLIC COMPOUNDS AND METHDS OF MAKING AND USING SAME | ZAFGEN CORPORATION (US) | 2012-01-26 | — | — | WO | disclosed |