Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 5/20 | 0.59 |
| ▸ | CNR2 | P34972 | 3/20 | 0.37 |
| ▸ | CCR2 | P41597 | 3/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.33 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4374615 | 0.91 | CNR1 (0.48) | CNR1CNR2CRHR1 | |
| SCHEMBL4372545 | 0.91 | CNR1 (0.48) | CNR1CNR2CRHR1 | |
| SCHEMBL4372526 | 0.90 | CNR1 (0.59) | CNR1CNR2CCR2CHRM3CHRM1 | |
| SCHEMBL5615341 | 0.81 | CNR1 (0.66) | CNR1CNR2CCR2CHRM1TRPV1 | |
| SCHEMBL4371310 | 0.80 | CNR1 (0.48) | CNR1CNR2TRPV1CRHR1 | |
| SCHEMBL4371181 | 0.80 | CNR1 (0.48) | CNR1CNR2TRPV1CRHR1 | |
| SCHEMBL4371187 | 0.80 | CNR1 (0.48) | CNR1CNR2TRPV1CRHR1 | |
| SCHEMBL13717371 | 0.80 | CNR1 (0.67) | CNR1CNR2CHRM1TRPV1TRPV4 | |
| SCHEMBL4368677 | 0.78 | ALDH1A1 (0.42) | CNR1CNR2TRPV4 | |
| SCHEMBL13717645 | 0.77 | CNR1 (0.70) | CNR1CNR2CCR2CHRM1TAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1749002-B1 | PYRROLE OR IMIDAZOLE AMIDES FOR TREATING OBESITY | HOFFMANN LA ROCHE (CH) | 2009-05-27 | — | — | EP | claimed |