SCHEMBL436813

SCHEMBL436813

COc1cc(C(=O)c2ccc(N)c(OC)c2)ccc1N

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.72
LMNA P02545 1/20 0.72
HTT P42858 1/20 0.72
L3MBTL1 Q9Y468 1/20 0.72
CYP3A4 P08684 3/20 0.68
TSHR P16473 2/20 0.68
CYP1A2 P05177 1/20 0.68
CYP2C9 P11712 1/20 0.68
CYP2C19 P33261 1/20 0.68
TUBB4A P04350 3/20 0.65
TUBB P07437 3/20 0.65
TUBA3C P0DPH7 3/20 0.65
TUBA1B P68363 3/20 0.65
TUBA4A P68366 3/20 0.65
TUBB4B P68371 3/20 0.65
TUBB3 Q13509 3/20 0.65
TUBB2A Q13885 3/20 0.65
TUBB8 Q3ZCM7 3/20 0.65
TUBA3E Q6PEY2 3/20 0.65
TUBA1A Q71U36 3/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8622568 0.98 ALDH1A1 (0.70) ALDH1A1LMNAHTTL3MBTL1CYP3A4
SCHEMBL8625272 0.93 ALDH1A1 (0.64) ALDH1A1LMNAHTTL3MBTL1CYP3A4
SCHEMBL8628407 0.93 ALDH1A1 (0.86) ALDH1A1LMNAHTTL3MBTL1CYP3A4
SCHEMBL8626158 0.93 ALDH1A1 (0.64) ALDH1A1LMNAHTTL3MBTL1CYP3A4
SCHEMBL4610035 0.91 CYP1A2 (0.62) ALDH1A1LMNAHTTL3MBTL1CYP3A4
SCHEMBL5891955 0.90 ALDH1A1 (0.60) ALDH1A1LMNAHTTL3MBTL1CYP3A4
SCHEMBL8626259 0.88 ALDH1A1 (0.58) ALDH1A1LMNAHTTL3MBTL1CYP3A4
SCHEMBL220432 0.86 LMNA (0.55) ALDH1A1LMNAHTTL3MBTL1CYP3A4
SCHEMBL72751 0.86 CA12 (0.69) ALDH1A1LMNAHTTL3MBTL1CYP3A4
SCHEMBL1804675 0.86 MAPK1 (0.60) ALDH1A1LMNAHTTL3MBTL1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 168 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070009751-A1 Polyamic acid resin composition modified with laminate nanometer silica sheet and polyimide prepared therefrom CHANG CHUN PLASTICS CO., LTD. (TW) 2007-01-11 US claimed
EP-1023168-B1 FIBER-REINFORCED PHTHALONITRILE COMPOSITE CURED WITH LOW-REACTIVITY AROMATIC AMINE CURING AGENT US GOV SEC NAVY (US) 2004-11-24 EP claimed
US-20040110014-A1 Organic-inorganic hybrid film material and its fabrication CHANG CHUN PLASTICS CO., LTD. (TW) 2004-06-10 US claimed
US-6001926-A Fiber-reinforced phthalonitrile composite cured with low-reactivity aromatic amine curing agent THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 1999-12-14 US claimed
US-12365763-B2 Phthalonitrile resins, methods of making same and compositions thereof HUNTSMAN ADVANCED MATERIALS AMERICAS LLC 2025-07-22 US disclosed
US-20230023657-A1 Phthalonitrile Resins, Methods Of Making Same And Compositions Thereof HUNTSMAN ADVANCED MATERIALS AMERICAS LLC 2023-01-26 US disclosed
US-20220403108-A1 Curable Compositions Of Benzoxazine And Phthalonitrile Resins HUNTSMAN ADVANCED MATERIALS AMERICAS LLC 2022-12-22 US disclosed
EP-4051727-A1 PHTHALONITRILE RESINS, METHODS OF MAKING SAME AND COMPOSITIONS THEREOF Huntsman Advanced Materials Americas LLC (US) 2022-09-07 EP disclosed
EP-4051726-A1 CURABLE COMPOSITIONS OF BENZOXAZINE AND PHTHALONITRILE RESINS Huntsman Advanced Materials Americas LLC (US) 2022-09-07 EP disclosed
US-11319410-B2 Precursor for polyimide and use thereof ETERNAL MATERIALS CO., LTD. (TW) 2022-05-03 US disclosed
WO-2021087193-A1 PHTHALONITRILE RESINS, METHODS OF MAKING SAME AND COMPOSITIONS THEREOF HUNTSMAN ADVANCED MATERIALS AMERICAS LLC (US) 2021-05-06 WO disclosed
WO-2021087197-A1 CURABLE COMPOSITIONS OF BENZOXAZINE AND PHTHALONITRILE RESINS HUNTSMAN ADVANCED MATERIALS AMERICAS LLC (US) 2021-05-06 WO disclosed
US-4058505-A Chain-extending amine end-capped polyimides UNIVERSITY OF NOTRE DAME DU LAC (US) 1977-11-15 US disclosed
US-4055543-A Chain-extending Schiff base terminated polyimides and method of preparation ALELIO GAETANO FRANCIS D 1977-10-25 US disclosed
US-4026871-A Chain-extending phenolic end-capped polyimides UNIVERSITY OF NOTRE DAME (US) 1977-05-31 US disclosed
US-4026833-A CROSSLINKED FOAMS UNIVERSITY OF NOTRE DAME (US) 1977-05-31 US disclosed
US-4026904-A Aromatic epoxy-terminated polyimides UNIVERSITY OF NOTRE DAME (US) 1977-05-31 US disclosed
US-3998786-A USEFUL FOR PREPARING COATINGS UNIVERSITY OF NOTRE DAME DU LAC (US) 1976-12-21 US disclosed
US-3996196-A Polyimide-metallo-phthalocyanines and their preparation UNIVERSITY OF NOTRE DAME DU LAC (US) 1976-12-07 US disclosed
US-3987003-A THERMALLY STABLE DIOXO AND DITHIO-BENZISOQUINOLINE COMPOSITIONS AND PROCESS OF SYNTHESIZING SAME THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (US) 1976-10-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12365763-B2 Phthalonitrile resins, methods of making same and compositions thereof PNN, PAH, CUL4B ALDH1A1 2253/4885LMNA 1315/4885HTT 118/4885
US-20230023657-A1 Phthalonitrile Resins, Methods Of Making Same And Compositions Thereof PNN, PAH, CUL4B ALDH1A1 2253/4885LMNA 1315/4885HTT 118/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.