Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 3/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MPL | P40238 | 2/20 | 0.39 |
| ▸ | RXRA | P19793 | 6/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL875406 | 0.86 | CDK8 (0.47) | CDK8HTR2ASLC6A4KCNH2MPL | |
| SCHEMBL876564 | 0.84 | CDK8 (0.46) | CDK8HTR2ASLC6A4KCNH2MPL | |
| SCHEMBL4375188 | 0.80 | SOS1 (0.48) | CDK8HTR2ASLC6A4KCNH2KDR | |
| SCHEMBL16853366 | 0.78 | ST14 (0.40) | — | |
| SCHEMBL4369986 | 0.78 | ST14 (0.55) | CDK8HTR2ASLC6A4KCNH2AR | |
| SCHEMBL3726016 | 0.77 | L3MBTL1 (0.40) | HTR2AAR | |
| SCHEMBL15096500 | 0.76 | CDK8 (0.46) | CDK8HTR2ASLC6A4KCNH2RXRA | |
| SCHEMBL4375086 | 0.76 | MEN1 (0.45) | CDK8KCNH2SCN9A | |
| SCHEMBL875837 | 0.75 | CDK8 (0.47) | CDK8HTR2ASLC6A4KCNH2MPL | |
| SCHEMBL876035 | 0.75 | CDK8 (0.45) | CDK8HTR2ASLC6A4KCNH2MPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |