Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 5/20 | 0.48 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | MPO | P05164 | 1/20 | 0.37 |
| ▸ | TPO | P07202 | 1/20 | 0.37 |
| ▸ | EPX | P11678 | 1/20 | 0.37 |
| ▸ | LPO | P22079 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16853366 | 0.80 | ST14 (0.40) | MPOTPOEPXLPOTSHR | |
| SCHEMBL21383965 | 0.80 | CDK8 (0.62) | SOS1CDK8EGFRKDRMPO | |
| SCHEMBL29442810 | 0.80 | CDK8 (0.62) | SOS1CDK8EGFRKDRMPO | |
| SCHEMBL4368153 | 0.80 | CDK8 (0.47) | CDK8HTR2ASLC6A4KCNH2KDR | |
| SCHEMBL4375086 | 0.78 | MEN1 (0.45) | SOS1CDK8KCNH2 | |
| SCHEMBL4345160 | 0.77 | SOS1 (0.65) | SOS1CDK8EGFRHTR2ASLC6A4 | |
| SCHEMBL923443 | 0.76 | ST14 (0.58) | SOS1EGFRHTR2ASLC6A4KCNH2 | |
| SCHEMBL3721624 | 0.74 | MPO (0.44) | EGFRHTR2ASLC6A4KCNH2NPC1 | |
| SCHEMBL3723565 | 0.73 | DPP4 (0.47) | SLC6A4KCNH2MAPTMPOTPO | |
| SCHEMBL1680724 | 0.73 | LTA4H (0.52) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |