Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MIF | P14174 | 2/20 | 0.45 |
| ▸ | TYR | P14679 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31485748 | 1.00 | LMNA (0.45) | LMNAHTTALOX15HSD17B10MIF | |
| Bromide SCHEMBL10939960 | 0.98 | LMNA (0.43) | LMNAHTTALOX15HSD17B10MIF | |
| SCHEMBL12958049 | 0.85 | KDM4E (0.53) | LMNAHTTALOX15HSD17B10MIF | |
| SCHEMBL22503911 | 0.82 | TYR (0.55) | LMNAHTTMIFTYRADRB1 | |
| SCHEMBL22499940 | 0.82 | TDP1 (0.53) | LMNAHTTALOX15HSD17B10MIF | |
| SCHEMBL29457584 | 0.81 | GABRA1 (0.52) | LMNAHTTALOX15HSD17B10MIF | |
| SCHEMBL51176 | 0.81 | TYR (0.48) | LMNAHTTALOX15HSD17B10MIF | |
| SCHEMBL67887 | 0.81 | GABRA1 (0.52) | LMNAHTTALOX15HSD17B10MIF | |
| SCHEMBL9198019 | 0.80 | LMNA (0.52) | LMNAALOX15HSD17B10ALDH1A1RECQL | |
| SCHEMBL5681804 | 0.80 | PDE10A (0.50) | LMNAHTTALOX15HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009012375-A2 | SQUARATE KINASE INHIBITORS | WYETH (US) | 2009-01-22 | — | — | WO | disclosed |