Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CPT2 | P23786 | 1/20 | 0.32 |
| ▸ | CPT1A | P50416 | 1/20 | 0.32 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.32 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.32 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.32 |
| ▸ | CBLB | Q13191 | 1/20 | 0.32 |
| ▸ | CRAT | P43155 | 1/20 | 0.30 |
| ▸ | GALR3 | O60755 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12985168 | 0.98 | SLC22A16 (0.36) | MAPTSLC22A16KMT2AATMCPT2 | |
| Hydrochloric Acid SCHEMBL14736711 | 0.92 | CBLB (0.30) | MAPTSLC22A16CBLB | |
| SCHEMBL14443964 | 0.92 | SLC22A16 (0.32) | SLC22A16KMT2AATM | |
| SCHEMBL13591404 | 0.92 | SLC22A16 (0.33) | MAPTSLC22A16KMT2AATMCPT2 | |
| SCHEMBL1755130 | 0.91 | SLC22A16 (0.31) | SLC22A16KMT2AATMCBLB | |
| Hydrochloric Acid SCHEMBL10337213 | 0.90 | TGFBR1 (0.34) | KMT2AATMPSMD14PLA2G1BHSP90AA1 | |
| Hydrochloric Acid SCHEMBL14736804 | 0.90 | CBLB (0.30) | SLC22A16CBLB | |
| SCHEMBL5077560 | 0.88 | CBLB (0.30) | CBLB | |
| SCHEMBL10337176 | 0.88 | TGFBR1 (0.35) | KMT2AATMPSMD14PLA2G1BHSP90AA1 | |
| SCHEMBL7559782 | 0.86 | KMT2A (0.35) | KMT2AATMCBLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009026248-A2 | HYDRAZIDE, AMIDE, PHTHALIMIDE AND PHTHALHYDRAZIDE ANALOGS AS INHIBITORS OF RETROVIRAL INTEGRASE | THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH, OFFICE OF TECHNOLOGY TRANSFER (US) | 2009-02-26 | — | — | WO | disclosed |
| EP-1500745-A1 | METHOD FOR PRODUCING PAPER AND AGENT FOR IMPROVING YIELD | Seiko PMC Corporation (JP) | 2005-01-26 | — | — | EP | disclosed |
| US-5115065-A | Bisquaternary ammonium (meth)acrylamide polymer for increased paper strength and filler retention | DIC-HERCULES CHEMICALS, INC. (JP) | 1992-05-19 | — | — | US | disclosed |