Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 10/20 | 0.61 |
| ▸ | MKNK2 | Q9HBH9 | 10/20 | 0.61 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.47 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.44 |
| ▸ | KMO | O15229 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | KIF11 | P52732 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30338756 | 0.83 | MKNK1 (0.59) | MKNK1MKNK2CA12CA1CA2 | |
| SCHEMBL1354541 | 0.81 | F7 (0.50) | MKNK1MKNK2ALDH1A1 | |
| SCHEMBL1354543 | 0.81 | F7 (0.50) | MKNK1MKNK2ALDH1A1 | |
| SCHEMBL7193261 | 0.81 | PTGS2 (0.52) | DHODHDPP4 | |
| SCHEMBL2925473 | 0.79 | MKNK1 (0.55) | MKNK1MKNK2CA12CA1CA2 | |
| SCHEMBL6026 | 0.79 | MKNK1 (0.55) | MKNK1MKNK2CA12CA1CA2 | |
| SCHEMBL7237272 | 0.77 | MKNK1 (0.54) | MKNK1MKNK2CA12CA1CA2 | |
| SCHEMBL29337469 | 0.76 | CYP2A6 (0.56) | MKNK1MKNK2CA12CA1CA2 | |
| SCHEMBL606654 | 0.76 | MKNK1 (1.00) | MKNK1MKNK2CA12CA1CA2 | |
| SCHEMBL30855339 | 0.76 | MKNK1 (1.00) | MKNK1MKNK2CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009012375-A2 | SQUARATE KINASE INHIBITORS | WYETH (US) | 2009-01-22 | — | — | WO | disclosed |