Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | CES2 | O00748 | 3/20 | 0.46 |
| ▸ | CES1 | P23141 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL436983 | 1.00 | TSHR (0.50) | TSHRMAPK1L3MBTL1CYP3A4ATM | |
| SCHEMBL4039683 | 1.00 | TSHR (0.50) | TSHRMAPK1L3MBTL1CYP3A4ATM | |
| SCHEMBL11814265 | 0.89 | ALDH1A1 (0.33) | TSHRMAPK1L3MBTL1CYP3A4ATM | |
| SCHEMBL16235776 | 0.87 | MAOA (0.47) | TSHRMAPK1L3MBTL1CYP3A4ATM | |
| Acetic Acid SCHEMBL9471064 | 0.87 | TSHR (0.50) | TSHRMAPK1L3MBTL1CYP3A4ATM | |
| SCHEMBL16235775 | 0.87 | MAOA (0.47) | TSHRMAPK1L3MBTL1CYP3A4ATM | |
| Acetic Acid SCHEMBL9471071 | 0.87 | TSHR (0.50) | TSHRMAPK1L3MBTL1CYP3A4ATM | |
| SCHEMBL10045039 | 0.79 | MEN1 (0.50) | TSHRMAPK1CYP3A4ALOX15LMNA | |
| SCHEMBL4201943 | 0.77 | TPMT (0.42) | CA1CA2GSK3B | |
| SCHEMBL8249574 | 0.77 | ALDH1A1 (0.44) | MAPK1ATMCES2CES1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 113 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-7048206-A | — | — | None | — | — | JP | disclosed |
| JP-6049797-A | — | — | None | — | — | JP | disclosed |
| EP-3615525-B1 | PYRROLE DERIVATIVES AS PLK1 INHIBITORS | SENTINEL ONCOLOGY LTD (GB) | 2024-12-25 | — | — | EP | disclosed |
| US-20240376089-A1 | 3-HYDROXY-5-(ISOXAZOL-5-YL) PYRIDINE FORMYLGLYCINE COMPOUNDS, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE | CHINA PHARMACEUTICAL UNIVERSITY (CN) | 2024-11-14 | — | — | US | disclosed |
| CN-116535399-B | 3-hydroxy-5- (isoxazol-5-yl) pyridine formyl glycine compound, preparation method, pharmaceutical composition and application | 中国药科大学 | 2024-02-27 | — | — | CN | disclosed |
| US-11884656-B2 | Pyrrole derivatives as PLK1 inhibitors | SENTINEL ONCOLOGY LIMITED (GB) | 2024-01-30 | — | — | US | disclosed |
| CN-116535399-A | 3-hydroxy-5- (isoxazol-5-yl) pyridine formyl glycine compound, preparation method, pharmaceutical composition and application | 中国药科大学 | 2023-08-04 | — | — | CN | disclosed |
| WO-2023142214-A1 | 3-HYDROXY-5-(ISOXAZOL-5-YL) PYRIDINE FORMYLGLYCINE COMPOUNDS, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE | 中国药科大学 | 2023-08-03 | — | — | WO | disclosed |
| CN-114524776-A | Tetrazole compound and application thereof | 中国科学院广州生物医药与健康研究院 | 2022-05-24 | — | — | CN | disclosed |
| US-20220135552-A1 | PYRROLE DERIVATIVES AS PLK1 INHIBITORS | SENTINEL ONCOLOGY LIMITED (GB) | 2022-05-05 | — | — | US | disclosed |
| JP-H0649797-A | SLIME CONTROL AGENT FOR PRODUCING PAPER | PERMACHEM ASIA LTD | 1994-02-22 | — | — | JP | disclosed |
| US-5114960-A | Rheumatoid arthritis; antiinflammatory and antishock agents; gastrointestinal and respiratory system disorders | HOFFMANN-LA ROCHE INC. (US) | 1992-05-19 | — | — | US | disclosed |
| EP-0409273-A2 | Substituted isoxazole and isothiazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1991-01-23 | — | — | EP | disclosed |
| US-4283403-A | Substituted isoxazolines for control of plant phytopathogens | ELI LILLY AND COMPANY (US) | 1981-08-11 | — | — | US | disclosed |
| US-4261728-A | PREEMERGENT ACTIVITY | MONSANTO COMPANY (US) | 1981-04-14 | — | — | US | disclosed |
| US-4187099-A | 3-Aryl-4-isothiazolecarboxylic acid and 3-aryl-4-isoxazolecarboxylic acid derivatives and their use as herbicides | MONSANTO COMPANY (US) | 1980-02-05 | — | — | US | disclosed |
| US-4144047-A | SOYBEANS | MONSANTO COMPANY (US) | 1979-03-13 | — | — | US | disclosed |
| US-4018645-A | Method of controlling slime during paper manufacture using alpha-chloro-acylbenzaldoxime derivatives | SOMAR MANUFACTURING CO., LTD. (JA) | 1977-04-19 | — | — | US | disclosed |
| US-3983246-A | N-(sulfonyloxy) benzimidoyl halides as bactericidal or fungicidal agents | FMC CORPORATION (US) | 1976-09-28 | — | — | US | disclosed |
| US-3968240-A | α-Chloro-o-acylbenzaldoxime derivatives as slime control agents | SOMAR MANUFACTURING CO., LTD. (JA) | 1976-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11884656-B2 | Pyrrole derivatives as PLK1 inhibitors | PLK1, CDK1, AURKC | TSHR 542/4885MAPK1 485/4885L3MBTL1 3964/4885 |
| US-20240376089-A1 | 3-HYDROXY-5-(ISOXAZOL-5-YL) PYRIDINE FORMYLGLYCINE COMPOUNDS, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE | HIF1AN, HIF1A, EGLN3 | TSHR 3911/4885MAPK1 2620/4885L3MBTL1 4572/4885 |
| US-20220135552-A1 | PYRROLE DERIVATIVES AS PLK1 INHIBITORS | PLK1, CDK1, AURKC | TSHR 542/4885MAPK1 485/4885L3MBTL1 3964/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.