Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 2/20 | 0.58 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.47 |
| ▸ | CASP1 | P29466 | 3/20 | 0.47 |
| ▸ | BLM | P54132 | 3/20 | 0.47 |
| ▸ | CASP7 | P55210 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4367099 | 0.83 | ALDH1A1 (0.46) | CDK5CDK5R1MEN1ALDH1A1KMT2A | |
| SCHEMBL4369473 | 0.80 | MEN1 (0.42) | CDK5CDK5R1MEN1ALDH1A1KMT2A | |
| SCHEMBL5158000 | 0.78 | CDK5 (0.58) | CDK5CDK5R1MEN1ALDH1A1KMT2A | |
| SCHEMBL30090954 | 0.77 | MAPT (0.50) | CDK5CDK5R1MEN1ALDH1A1KMT2A | |
| SCHEMBL1988192 | 0.74 | CDK5 (1.00) | CDK5CDK5R1MEN1ALDH1A1KMT2A | |
| SCHEMBL7149792 | 0.71 | XDH (0.59) | CDK5CDK5R1MEN1ALDH1A1KMT2A | |
| SCHEMBL7146850 | 0.71 | XDH (0.59) | CDK5CDK5R1MEN1ALDH1A1KMT2A | |
| SCHEMBL1057968 | 0.70 | ALDH1A1 (0.43) | CDK5CDK5R1MEN1ALDH1A1KMT2A | |
| SCHEMBL3456697 | 0.69 | XDH (0.54) | CDK5CDK5R1MEN1ALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL28275525 | 0.69 | ALDH1A1 (0.42) | CDK5CDK5R1MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7598256-B2 | Parkinson's disease; antidepressants; cognition activators; attention deficit disorders; narcolepsy; N,N-dimethyl-4-(2-furyl)-1H-pyrrolo[2,3- d]pyrimidine-2-amine | VERNALIS RESEARCH LIMITED (GB) | 2009-10-06 | — | — | US | disclosed |
| EP-1363639-B1 | PYRROLO 2,3-d PYRIMIDINE AND THEIR USE AS PURINERGIC RECEPTOR ANTAGONISTS | VERNALIS RES LTD (GB) | 2008-08-20 | — | — | EP | disclosed |
| US-7098333-B2 | Pyrrolo[2,3-d]pyrimidine and their use as purinergic receptor antagonists | VERNALIS RESEARCH LIMITED (GB) | 2006-08-29 | — | — | US | disclosed |
| US-20060128731-A1 | Pyrrolo [2,3-d] pyrimidine and their use as purinergic receptor antagonists | VERNALIS RESEARCH LIMITED | 2006-06-15 | — | — | US | disclosed |
| US-20040092537-A1 | Pyrrolo[2,3-d]pyrimidine and their use as purinergic receptor antagonists | VERNALIS RESEARCH LIMITED (GB) | 2004-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060128731-A1 | Pyrrolo [2,3-d] pyrimidine and their use as purinergic receptor antagonists | CHRNA6, CNR1, ADORA2A | CDK5 495/4885CDK5R1 179/4885MEN1 4873/4885 |
| US-20040092537-A1 | Pyrrolo[2,3-d]pyrimidine and their use as purinergic receptor antagonists | CNR1, CNR2, CHRNA6 | CDK5 938/4885CDK5R1 318/4885MEN1 4883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.